08-115

Rat Collagen Type I

from rat tail, liquid, 2-5 mg/mL, suitable for cell culture, used for 3D gel formation

• Szinonimák: Rat tail collagen, Rat tail collagen type I
• UNSPSC kód: 12352202
• eCl@ss: 32160405
• NACRES: NA.75

Tulajdonságok

• Terméknév: Collagen Type I, rat tail,
• biológiai forrás: rat
• Minőségi szint: 100
• Forma: liquid
• gyártó/kereskedő neve: Upstate^®
• technika/technikák: cell culture | mammalian: suitable
• bemenet: sample type hematopoietic stem cell(s); sample type mesenchymal stem cell(s); sample type induced pluripotent stem cell(s); sample type epithelial cells; sample type pancreatic stem cell(s); sample type neural stem cell(s); sample type: mouse embryonic stem cell(s)
• NCBI elérési szám: NM_000088.3
• UniProt elérési szám: P02452
• kiszállítva: wet ice
• tárolási hőmérséklet: 2-8°C
• Géninformáció: rat ... COL1A1(29393)

Leírás

Általános leírás

In humans, type I collagen is the most abundant and broadly expressed collagen. This heterotrimer contains two alpha 1 (I) chains and one alpha 2 (I) chain. Collagen type I α 1 (COL1A1), a major component of collagen type I, codes for pro-α 1 chains of type I collagen. It has repeating Gly-Xaa-Yaa tri-peptides motifs. The collagen alpha-1(I) chain protein is a member of the collagen complex superfamily. COL1A1 has a von Willebrand factor type C (vWFC) domain, a collagen triple-helix repeat, and a fibrillar collagen C-terminal domain (COLF).

Alkalmazás

Collagen Type I, rat tail has been used:

• for collagen 3D proliferation assays
• for atelocollagen proliferation assays
• in a comparative study to make microcapsules for templating on mesoporous cores of pure vaterite calcium carbonate (CaCO3) crystals to evaluate the structure-property relationship
• in coverslip coating to grow the human cerebral microvascular endothelial cell line (hCMEC/D3) for creating a cell coculture and chronic subdural hematoma (CSDH) patient hematoma sample induced injury model

Biokémiai/fiziológiai hatások

Collagen type I α 1 (COL1A1) plays a key role in chemoresistance and may act as a therapeutic target. It is involved in carboplatin-resistant ovarian cancer (OV). COL1A1 serves as an oncogene in the development of colorectal cancer (CRC). Dominant inherited COL1A1 gene mutations result in connective tissue disorders such as osteogenesis imperfecta (OI).

Minőség

Routinely evaluated by testing for uniform gelation and for attachment of and spreading of PC-12 rat cells

Fizikai forma

0.02N acetic acid, pH 3.67

Tárolás és stabilitás

1 year at 4°C

Jogi információk

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable