141101P
Avanti
Brain Extract Polar
Avanti Research™ - A Croda Brand
Szinonimák:
Brain Polar Lipid Extract (Porcine)
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
![(3RS)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazin-7-one certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland](/deepweb/assets/sigmaaldrich/product/structures/277/860/e3312473-93c3-4ac2-bbb9-dfedf9b6ef2b/640/e3312473-93c3-4ac2-bbb9-dfedf9b6ef2b.png)
Forma
powder
kiszerelés
pkg of 1 × 100 mg (141101P-100mg)
pkg of 5 × 100 mg (141101P-500mg)
gyártó/kereskedő neve
Avanti Research™ - A Croda Brand
lipidtípus
lipid extracts
kiszállítva
dry ice
tárolási hőmérséklet
−20°C
Általános leírás
Brain Extract Polar comprises phosphatidylethanolamine as a major lipid component. It also contains phosphatidylserine and phosphatidylcholine. The minor components include the phosphatidic acid and phosphatidylinositol.
Brain Polar Lipid Extract is derived from the total lipid extract by precipitation with acetone followed by extraction of the acetone insoluble material with diethyl ether.
Alkalmazás
Brain Extract Polar has been used in parallel artificial membrane permeability assay (PAMPA) for coating membrane to evaluate blood brain-barrier permeability, and for drug permeability studies.
Biokémiai/fiziológiai hatások
Lipid extracts from the mammalian tissues like brain, kidney and liver are used in generating model membranes for mimicking real membranes. Brain lipid, especially the polar fraction play a key role in the inhibition of prion seeded amyloid formation.
Kiszerelés
5 mL Clear Glass Sealed Ampule (141101P-100mg)
5 mL Clear Glass Sealed Ampule (141101P-500mg)
Jogi információk
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
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Analitikai tanúsítványok (COA)
Lot/Batch Number
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Az ügyfelek ezeket is megtekintették
Rapid screening of brain-penetrable antioxidants from natural products by blood-brain barrier specific permeability assay combined with DPPH recognition
Zhu J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 151, 42-48 (2018)
David S Wexler et al.
Journal of biomolecular screening, 10(4), 383-390 (2005-06-21)
Solubility and permeability are intimately linked in drug absorption processes. They have, however, been traditionally assayed separately. To support this linkage, a combined solubility/permeability assay was developed for determining absorption properties of chemical entities. First, solubility is determined at 4
Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs
Hallifax D, et al.
European Journal of Pharmaceutical Sciences, 45(5), 570-574 (2012)
Endogenous brain lipids inhibit prion amyloid formation in vitro
Hoover CE, et al.
Journal of Virology, 91(9), e02162-e02116 (2017)
Laura Campello et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(1), 142-159 (2020-02-07)
It is well established that oxidative stress and inflammation are common pathogenic features of retinal degenerative diseases. ITH12674 is a novel compound that induces the transcription factor Nrf2; in so doing, the molecule exhibits anti-inflammatory, and antioxidant properties, and affords
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