Összes fotó(1)
Fontos dokumentumok
765341
Gold nanoparticles
20 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O
Szinonimák:
Gold nanoparticles NH2 functionalized, Au NP NH2, Gold Colloid
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Méret kiválasztása
1 ML
181 500,00 Ft
181 500,00 Ft
Az elérhetőséggel kapcsolatos kérdésekkel kérjük, forduljon Vevőszolgálatunkhoz.
Megrendelés igénylése nagy tételben
Összes fotó(1)
Méret kiválasztása
Nézet módosítása
1 ML
181 500,00 Ft
About This Item
UNSPSC kód:
12162002
NACRES:
NA.23
181 500,00 Ft
Az elérhetőséggel kapcsolatos kérdésekkel kérjük, forduljon Vevőszolgálatunkhoz.
Megrendelés igénylése nagy tételben
Javasolt termékek
Anyagok
PEG 5000
Minőségi szint
Forma
dispersion in H2O
nanoparticles
kiszerelés
poly bottle of 1 mL
OD
50
átmérő
20 nm
pH
6.0-8.0 (25 °C)
oldhatóság
water: miscible
sűrűség
1.00 g/cm3
λmax
520 nm
funkcionális csoport
amine
tárolási hőmérséklet
2-8°C
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Általános leírás
Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which have Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.[1][2][3][4]
Alkalmazás
Functionalized particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Several other specific applications have been listed below:
- Since they adhere to cell membranes, AuNPs are used in cellular and intracellular targeting in targeted drug delivery applications and may also be used in biodistribution studies
- AuNPs may also be used in photothermal therapy and radiotherapy.
- Proposed applications of gold nanoparticles are as:drug delivery agents for cancer therapy, coatings, plastics, nanowire, nanofiber, textiles, catalyst applications.
- They may also be used in carrying siRNA which acts against human prostate carcinoma cells by inhibiting a specific cancer gene.[5][4]
Tulajdonságok és előnyök
- The negatively charged siRNA-PEG complex, attached to positively charged GNPs, is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.[5][4]
- The PEG coating decreases the cytotoxicity and increases effciciency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.[1]
Tárolási osztály kódja
12 - Non Combustible Liquids
WGK
WGK 2
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Cikkek
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Biomaterials science integrates smart materials into biological research, requiring a deep understanding of biological systems.
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