49920

Glycerol formal

≥98.0% (GC)

• Szinonimák: 1,3(or 2,3)-O-Methylene-1,2,3-propanetriol
• Tapasztalati képlet (Hill-képlet): C₄H₈O₃
• CAS-szám: 99569-11-6
• Molekulatömeg: 104.10
• Beilstein: 103206
• MDL-szám: MFCD10039829
• UNSPSC kód: 12352100
• PubChem Substance ID: 57651229
• NACRES: NA.22

Tulajdonságok

• Minőségi szint: 200
• Teszt: ≥98.0% (GC)
• tartalmaz: ~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer
• összetétel: 5-hydroxy-1,3-dioxane, ~60% ; 4-hydroxymethyl-1,3-dioxolane, ~40%
• törésmutató: n20/D 1.451 (lit.); n20/D 1.451
• bp: 192-193 °C (lit.)
• sűrűség: 1.203 g/mL at 25 °C (lit.)
• funkcionális csoport: ether; hydroxyl
• SMILES string: OCC1COCO1.OC2COCOC2
• InChI: 1S/2C4H8O3/c5-4-1-6-3-7-2-4;5-1-4-2-6-3-7-4/h2*4-5H,1-3H2
• Nemzetközi kémiai azonosító kulcs: JIUMSISXCKWZTA-UHFFFAOYSA-N

Leírás

Általános leírás

Glycerol formal (GF) is a light glycerol acetal that is composed of ~60% 5-hydroxy-1,3-dioxane and ~40% 4-hydroxymethyl-1,3-dioxolane. It can be prepared by reacting glycerol and formaldehyde in the presence of acid catalyst. The potential of GF as an injection solvent for use in toxicity testing has been reported.

Alkalmazás

Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery. Glycerol formal was used as a vehicle for antibiotic delivery in rats.

Glycerol formal may be used in the multi-step synthesis of 9-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]guanine (2′-nor-2′-deoxyguanosine), an analog of acyclovir. It may be used in the preparation of 4-substituted dioxolanes.

Biztonsági adatok

• WGK: WGK 3
• Egyéni védőeszköz: Eyeshields, Gloves, type ABEK (EN14387) respirator filter