T6397

3,3′,5-Triiodo-L-thyronine sodium salt

powder, BioReagent, suitable for cell culture

• Sinônimo(s): Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T₃
• Fórmula empírica (Notação de Hill): C₁₅H₁₁I₃NNaO₄
• Número CAS: 55-06-1
• Peso molecular: 672.96
• Beilstein: 8179867
• Número CE: 200-223-5
• Número MDL: MFCD00002594
• Código UNSPSC: 12352209
• ID de substância PubChem: 24900372
• NACRES: NA.77

Propriedades

• fonte biológica: synthetic
• Nível de qualidade: 200
• linha de produto: BioReagent
• Ensaio: ≥95%
• forma: powder
• potência: 0.02-50 ng/mL (lit.)
• técnica(s): cell culture | mammalian: suitable
• solubilidade: ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to yellow
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
• chave InChI: SBXXSUDPJJJJLC-YDALLXLXSA-M
• Informações sobre genes: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

Descrição

Descrição geral

3,3′,5′-Triiodo-L-thyronine (T₃) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T₄) serves as a precursor for T₃ and is generated in extrathyroidal tissues.

Aplicação

3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice. It has also been used In cell culturing of hippocampal, retinal, proximal tubule and glomerular explant.

Ações bioquímicas/fisiológicas

3,3′,5′-Triiodo-L-thyronine (T₃) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T₃ regulates cell differentiation and protein expression. The interaction of T₃ with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T₃ hormone is reduced in hypothyroidism.

forma física

powder-20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Reconstituição

To prepare 20 μg/ml stock solution: add 1ml 1N NaOH per mg 3,3′, 5-triiodo-L-thyronine; gently swirl to dissolve. To this, add 49 ml sterile medium per ml 1N NaOH added.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)