T2877

3,3′,5-Triiodo-L-thyronine

≥95% (HPLC), powder

• Sinônimo(s): O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T₃
• Fórmula empírica (Notação de Hill): C₁₅H₁₂I₃NO₄
• Número CAS: 6893-02-3
• Peso molecular: 650.97
• Beilstein: 2710227
• Número CE: 229-999-3
• Número MDL: MFCD00002593
• Código UNSPSC: 51111800
• ID de substância PubChem: 24900088
• NACRES: NA.32

Propriedades

• fonte biológica: synthetic (organic)
• esterilidade: non-sterile
• Ensaio: ≥95% (HPLC)
• forma: powder
• atividade óptica: [α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2
• técnica(s): transfection: suitable
• pf: 234-238 °C (lit.)
• solubilidade: 4 M NH₄OH in methanol: 5 mg/mL, clear to very slightly hazy, colorless to light yellow
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
• chave InChI: AUYYCJSJGJYCDS-LBPRGKRZSA-N
• Informações sobre genes: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

Descrição

Aplicação

3,3′,5-Triiodo-L-thyronine can be used for Insulin-like growth factor I assays performed by using a double antibody radioimmunoassay. The product can also be used for in vitro transfection of 293T cells.

Ações bioquímicas/fisiológicas

3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine enhances mood and neuropsychological function. The product also positively regulates the hepatic FGF21 expression and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation. Additionally, the product facilitates the normal body growth in children and is pivotal for central nervous system maturation in foetus.

Nota de preparo

3,3′,5-Triiodo-L-thyronine dissolves in 4M NH4OH in MeOH at 5 mg/ml to yield a colorless to light yellow, clear to very slightly hazy solution.

Outras notas

This product has not been tested for cell culture. A sterile version is offered that is suitable for cell culture. The T5516 is a sterile preparation that is cell culture tested. Please review the product page for product T2877

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H372
• Declarações de precaução: P260 - P264 - P270 - P314 - P501
• Classificações de perigo: STOT RE 1
• Órgãos-alvo: Thyroid,Cardio-vascular system,Kidney
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves