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Key Documents

P0503

Sigma-Aldrich

O-Phosphorylethanolamine

Sinônimo(s):

2-Aminoethyl dihydrogen phosphate, O-Phosphocolamine, O-Phosphoethanolamine, Colaminephosphoric acid

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About This Item

Fórmula linear:
NH2CH2CH2OPO3H2
Número CAS:
Peso molecular:
141.06
Beilstein:
1758916
Número CE:
Número MDL:
Código UNSPSC:
12161700
ID de substância PubChem:
NACRES:
NA.25

forma

powder

Nível de qualidade

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

NCCOP(O)(O)=O

InChI

1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)

chave InChI

SUHOOTKUPISOBE-UHFFFAOYSA-N

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Aplicação

O-Phosphorylethanolamine has been used:
  • in LHC-8 medium as a supplement in culturing the transformed human liver epithelial (THLE)-2 and THLE-3 cells
  • in C-reactive protein (CRP) binding sucrose flotation experiment
  • to incubate phosphomonoesters with anion-exchange chromatography (AEC) fractions for the detection of phosphatase activity
  • to add in the washed beads for the preparation of phosphorylethanolamine (Pet) -conjugated sepharose column for chromatographic purification of mutant CRP

Ações bioquímicas/fisiológicas

Phosphorylethanolamine participates in phospholipid metabolism. Its release can be stimulated occasionally by depolarizing stimuli. Reduction of phosphorylethanolamine levels has been observed in Alzheimer′s and Huntington′s disease.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Phosphoethanolamine-complexed C-reactive protein: a pharmacological-like macromolecule that binds to native low-density lipoprotein in human serum
Singh SK, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 394(1-2), 94-98 (2008)
The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection
Gang TB, et al.
Test, jbc-M112 (2012)
Phosphoethanolamine and ethanolamine are decreased in Alzheimer's disease and Huntington's disease
Ellison David W, et al.
Brain Research, 417(2), 389-392 (1987)
Novel Phospholipase A activity secreted byLegionella species
Flieger A, et al.
Journal of Bacteriology, 182(5), 1321-1327 (2000)
Conan K Wang et al.
The Journal of biological chemistry, 287(52), 43884-43898 (2012-11-07)
Cyclotides are a family of plant-derived circular proteins with potential therapeutic applications arising from their remarkable stability, broad sequence diversity, and range of bioactivities. Their membrane-binding activity is believed to be a critical component of their mechanism of action. Using

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