S7821

Sulfadoxin

≥95% (TLC)

• Sinônimo(s): 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide, Sulfadoxine
• Fórmula empírica (Notação de Hill): C₁₂H₁₄N₄O₄S
• Número CAS: 2447-57-6
• Peso molecular: 310.33
• Beilstein: 625453
• Número CE: 219-504-9
• Número MDL: MFCD00792890
• Código UNSPSC: 51101500
• ID de substância PubChem: 24899765
• NACRES: NA.85

Propriedades

• Ensaio: ≥95% (TLC)
• forma: powder
• cor: white
• solubilidade: ethanol: NH₄OH (9:1): soluble 20 mg/mL
• espectro de atividade do antibiótico: parasites
• Modo de ação: enzyme | inhibits
• cadeia de caracteres SMILES: COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC
• InChI: 1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
• chave InChI: PJSFRIWCGOHTNF-UHFFFAOYSA-N

Descrição

Descrição geral

Chemical structure: sulfonamide

Aplicação

Sulfadoxine is a sulfonamide antibiotic used in combination with pyrimethamine for the treatment or prevention of malaria. It is also used to treat various infections in livestock. Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in patients where chloroquine resistance is suspected. It is used to study infections caused by Toxoplasma gondii and has been used to prevent infections after surgery during animal studies.

Ações bioquímicas/fisiológicas

Sulfadoxine is a sulfonamide antibacterial that inhibits dihydropteroate synthase (DHPS), an enzyme that transforms 4-aminobenzoic acid (PABA) in the synthesis of dihydropteroic acid. This enzyme is also a component of the folate metabolic pathway and is upstream of dihydrofolate reductase (DHFR).

Outras notas

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids