P7130
Puromycin aminonucleoside
Sinônimo(s):
3′-Amino-3′-deoxy-N6,N6-dimethyladenosine
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100 MG
R$ 5.787,00
500 MG
R$ 18.560,00
1 G
R$ 34.318,00
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Alterar visualização
100 MG
R$ 5.787,00
500 MG
R$ 18.560,00
1 G
R$ 34.318,00
About This Item
Fórmula empírica (Notação de Hill):
C12H18N6O3
Número CAS:
Peso molecular:
294.31
Beilstein:
93902
Número CE:
Número MDL:
Código UNSPSC:
51281912
ID de substância PubChem:
NACRES:
NA.85
Produtos recomendados
Formulário
powder
Nível de qualidade
solubilidade
H2O: soluble 50 mg/mL
espectro de atividade do antibiótico
Gram-positive bacteria
neoplastics
parasites
Modo de ação
protein synthesis | interferes
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
CN(C)c1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](N)[C@@H]3O
InChI
1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7+,9+,12-/m1/s1
chave InChI
RYSMHWILUNYBFW-VENHTOENSA-N
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Descrição geral
Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin. It is useful in nephrology research, like studies of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and nitrite (NOx) metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome are studied. Puromycin aminonucleoside-induced nephrosis in rats has been studied with respect to the production of reactive oxygen species during the acute phase. Puromycin aminonucleoside is used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability.
Aplicação
Puromycin aminonucleoside has been used:
- as a selection marker for the infected cells for the transfection of lentivirus
- as a component of fresh medium for transfection and infection assays
- to subcutaneously induce puromycin aminonucleoside nephrosis to investigate the mRNA and protein levels of nephrin and podocin before the onset of proteinuria
Ações bioquímicas/fisiológicas
Puromycin aminonucleoside is used to study human glomerular disease by inducing damage of murine glomerular podocytes and is used to study glomerular function and morphology.
Outras notas
Keep container tightly closed in a dry and well-ventilated place.
Palavra indicadora
Warning
Frases de perigo
Classificações de perigo
STOT RE 2
Órgãos-alvo
Kidney
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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