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Sigma-Aldrich

Chloramphenicol

Chloramphenicol, CAS 56-75-7, is a synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.

Sinônimo(s):

Chloramphenicol

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About This Item

Fórmula empírica (Notação de Hill):
C11H12Cl2N2O5
Número CAS:
56-75-7
Peso molecular:
323.13
Número MDL:
MFCD00078159
Código UNSPSC:
12352200

Nível de qualidade

100

Ensaio

≥97% (by Assay)

forma

crystalline powder

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze

cor

gray to off-white

solubilidade

water: 2.5 mg/mL
methanol: 35 mg/mL
ethanol: soluble

Condições de expedição

ambient

temperatura de armazenamento

10-30°C

InChI

1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)

chave InChI

WIIZWVCIJKGZOK-UHFFFAOYSA-N

Categorias relacionadas

Descrição geral

Synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.
Synthetic bacteriostatic antibiotic that inhibits the translation of RNA to protein by binding to the 50S ribosomal subunit, blocking the peptidyl transferase reaction. Chloramphenicol resistance is encoded by the resistance gene cat, whose product, chloramphenicol acetyltransferase, inactivates the antibiotic via acetylation. Typically used at 30-50 µg/ml for selection of chloramphenicol-resistant Escherichia coli.

Ações bioquímicas/fisiológicas

Potency: ≥970 µg/mg
Primary Target
trasnslation of RNA

Outras notas

Lech, K., and Brent, R. 1995. in Current Protocols in Mol. Biol. Vol. 1, (Ausubel, F.M., et al., Eds.) John Wiley & Sons, New York.
Lu, J., and Jiang, C. 1993. Biochem. Biophys. Res. Commun.196, 12.
Saltarelli, M.J., et al. 1993. Virol.197, 35.
Holt, J.T. 1992. Ann. N.Y. Acad. Sci.660, 88.
Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, NY, p. 1.6, A.6.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Health hazardCorrosion
GHS08,GHS05

Palavra indicadora

Danger

Frases de perigo

H318,H351,H361fd

Classificações de perigo

Carc. 2 - Eye Dam. 1 - Repr. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Certificados de análise (COA)

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Supelco

31667

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Ampicilina

Sigma-Aldrich

A9518

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