R6520

Rolipram

≥98% (HPLC), solid, cAMP-specific phosphodiesterase (PDE4) inhibitor

• Synonym(e): 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK 62711
• Empirische Formel (Hill-System): C₁₆H₂₁NO₃
• CAS-Nummer: 61413-54-5
• Molekulargewicht: 275.34
• EG-Nummer: 262-771-1
• MDL-Nummer: MFCD00270906
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24278196
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: Rolipram, solid, ≥98% (HPLC)
• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: white to off-white
• Löslichkeit: H₂O: 0.2 mg/mL; ethanol: 7 mg/mL; DMSO: 7.3 mg/mL
• SMILES String: COc1ccc(cc1OC2CCCC2)C3CNC(=O)C3
• InChI: 1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
• InChIKey: HJORMJIFDVBMOB-UHFFFAOYSA-N
• Angaben zum Gen: human ... LITAF(9516) , PDE3A(5139) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE5A(8654) , PDE7A(5150) ; mouse ... Pde4a(18577) ; rat ... Adora1(29290) , Pde1b(29691) , Pde2a(81743) , Pde3a(50678) , Pde4a(25638) , Pde4b(24626) , Pde4c(290646) , Pde5a(171115)

Beschreibung

Allgemeine Beschreibung

Rolipram enhances tissue protection, anatomical repair and functional recovery. It is used to treat asthma, arthritis, Huntington′s disease and multiple sclerosis. Rolipram inhibits injury-induced reductions in cyclic AMP, which is associated with acute central nervous system injury.[1] It functions as an antidepressant, stimulates neurite outgrowth and axonal regeneration in the presence of myelin inhibitors.[2]

Anwendung

Rolipram has been used:

• to investigate its effects on testicular torsion–detorsion injury(36)
• to block the effects of phosphodiesterase-4 (PDE4)(37)
• as a component in chemically induced long-term potentiation (cLTP) induction media(38)

Biochem./physiol. Wirkung

Selective cAMP-specific phosphodiesterase (PDE4) inhibitor.

Leistungsmerkmale und Vorteile

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves