C9915

ω-Conotoxin GVIA

≥97% (HPLC)

• Empirische Formel (Hill-System): C₁₂₀H₁₈₂N₃₈O₄₃S₆
• CAS-Nummer: 106375-28-4
• Molekulargewicht: 3037.35
• MDL-Nummer: MFCD00076620
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥97% (HPLC)
• Form: powder
• Zusammensetzung: Peptide content, ~70%
• Lagertemp.: −20°C
• Angaben zum Gen: human ... CACNA1B(774) ; mouse ... CACNA1B(12287) ; rat ... CACNA1B(257648)

Beschreibung

Amino Acid Sequence

Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 [Disulfide Bridges: 1-16, 8-19, 15-26]

Anwendung

ω-Conotoxin GVIA has been used as an antagonist for N-type calcium channel (CaV2.2) in various studies.[1][2][3]

Powerful probe for exploring the vertebrate pre-synaptic terminal.

Biochem./physiol. Wirkung

ω-Conotoxin GVIA is a 27 amino acid neurotoxin containing three disulfide bonds.[4] It inhibits central neurotransmitter release[5] and also exhibits antihypertensive, analgesic and neuroprotective activities.[6]

Blocks specific voltage-dependent N-type Ca²⁺ channels in neurons, but not in muscle; does not bind to either the dihydropyridine or verapamil binding sites; peptide first isolated from the marine snail Conus geographus L.

Sonstige Hinweise

Lyophilized from 0.1% TFA in H2O

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)