B133

(S)-(−)-Bay K8644

≥98% (HPLC), Ca2+ channel activator, solid

• Synonym(e): S-(−)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
• Empirische Formel (Hill-System): C₁₆H₁₅F₃N₂O₄
• CAS-Nummer: 98625-26-4
• Molekulargewicht: 356.30
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891582
• NACRES: NA.77
• MDL number: MFCD00153769
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• Produktname: (S)-(−)-Bay K8644, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: yellow
• solubility: H₂O: slightly soluble, ethanol: soluble (Organic solutions are stable for at least 20 days at RT.)
• storage temp.: 2-8°C
• SMILES string: COC(=O)C1=C(C)NC(C)=C([C@H]1c2ccccc2C(F)(F)F)[N+]([O-])=O
• InChI: 1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1
• InChI key: ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
• Gene Information: human ... ADORA3(140) ; rat ... Adora1(29290), Adora2a(25369)

Beschreibung

General description

(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca²⁺ channel activator.[1] It is an enantiomer of Bay K 8644.[2]

Application

(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices.[1] It has also been used as a LTCC agonist to induce arrhythmia in rats.[3]

Biochem/physiol Actions

(S)-(-)-Bay K8644 enhances Ca²⁺ current, whereas the (+)-Bay K 8644 is a weak Ca²⁺ channel antagonist.[2] Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.[4]

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold with the permission of Bayer AG.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319
• pcodes: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves