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G6639

Sigma-Aldrich

Guanidinthiocyanat

≥97% (titration)

Synonym(e):

Guanidin-rhodanid, Guanidiniumthiocyanat

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About This Item

Lineare Formel:
NH2C(=NH)NH2 · HSCN
CAS-Nummer:
593-84-0
Molekulargewicht:
118.16
Beilstein:
3563461
EG-Nummer:
209-812-1
MDL-Nummer:
MFCD00013027
UNSPSC-Code:
12352209
PubChem Substanz-ID:
24895264
NACRES:
NA.55

Biologische Quelle

synthetic

Qualitätsniveau

200

Assay

≥97% (titration)

Form

powder or crystals

Methode(n)

RNA extraction: suitable

Farbe

white to off-white

mp (Schmelzpunkt)

120-122 °C (lit.)

Löslichkeit

water: 4 M, clear, colorless

Anionenspuren

chloride (Cl-): ≤2.5%

SMILES String

SC#N.NC(N)=N

InChI

1S/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H

InChIKey

ZJYYHGLJYGJLLN-UHFFFAOYSA-N

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Anwendung

Guanidine thiocyanate has been used:
  • as a denaturing agent to study its effects on surface activity of globular protein
  • for the extraction of total RNA from primary hepatocytes
  • as a component of the incubating buffer for extraction of DNA from human bone
  • as a component of the guanidine thiocyanate (GITC) lysis buffer for extraction of elephant shark DNA
  • as a component of lysis solution for extraction of RNA from rat pancreatic tissues
Chaotropisches Reagens und starker Denaturant; löst Zellen auf

Biochem./physiol. Wirkung

Guanidine thiocyanate (GTC) is a powerful protein denaturant and can denature endogenous ribonucleases. It plays a role in separation of ribosomal ribonucleic acid (rRNA) from ribosomes. GTC in combination with phenol and chloroform can be used in isolation of total RNA from cells and tissues.

Piktogramme

CorrosionExclamation mark
GHS05,GHS07

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1C

Zusätzliche Gefahrenhinweise

EUH032

Lagerklassenschlüssel

8B - Non-combustible corrosive hazardous materials

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Analysenzertifikate (COA)

Lot/Batch Number
WXBF2667V
WXBF2503V
WXBF3958V
WXBF1033V
WXBF2154V

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Die Dokumentenbibliothek aufrufen

Emilia Bramanti et al.
Analytical biochemistry, 351(1), 100-113 (2006-01-28)
In this article, a multidimensional dynamic surface tension detector (DSTD), in a parallel configuration with a UV-visible diode array absorbance detector, is presented in a novel flow injection analysis (FIA) application to study the effects of chemical denaturants urea, guanidinium
DNA fromMycobacterium tuberculosisIdentified in Mediaeval Human Skeletal Remains Using Polymerase Chain Reaction
Taylor M G, et al.
Journal of Archaeological Science, 23, 789-798 (1996)
Angela Molinaro et al.
Cell metabolism, 29(6), 1400-1409 (2019-04-16)
Phosphatidylinositol-3-kinase (PI3K) activity is aberrant in tumors, and PI3K inhibitors are investigated as cancer therapeutics. PI3K signaling mediates insulin action in metabolism, but the role of PI3K isoforms in insulin signaling remains unresolved. Defining the role of PI3K isoforms in
Julian R Peat et al.
F1000Research, 6, 526-526 (2017-06-06)
Methylation of CG dinucleotides constitutes a critical system of epigenetic memory in bony vertebrates, where it modulates gene expression and suppresses transposon activity. The genomes of studied vertebrates are pervasively hypermethylated, with the exception of regulatory elements such as transcription
Nicolas Chuvin et al.
Cellular and molecular gastroenterology and hepatology, 4(2), 263-282 (2017-07-29)
Transforming growth factor beta (TGFβ) acts either as a tumor suppressor or as an oncogene, depending on the cellular context and time of activation. TGFβ activates the canonical SMAD pathway through its interaction with the serine/threonine kinase type I and II
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