917648

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride

≥95%

• Synonym(e): Semi-flexible linker for PROTAC^® development
• Empirische Formel (Hill-System): C₁₂H₁₈ClNO
• CAS-Nummer: 1187927-60-1
• Molekulargewicht: 227.73
• MDL-Nummer: MFCD11506185
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95%
• Form: powder
• Eignung der Reaktion: reagent type: linker
• Funktionelle Gruppe: hydroxyl
• Lagertemp.: 2-8°C
• SMILES String: OCC1=CC=C(C2CCNCC2)C=C1.Cl
• InChI: 1S/C12H17NO.ClH/c14-9-10-1-3-11(4-2-10)12-5-7-13-8-6-12;/h1-4,12-14H,5-9H2;1H
• InChIKey: JSCRYCUDRVBGRN-UHFFFAOYSA-N

Beschreibung

Anwendung

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Sonstige Hinweise

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable