917109

2-(3-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid

• Synonym(e): Semi-flexible linker for PROTAC^® development
• Empirische Formel (Hill-System): C₁₈H₂₅NO₄
• CAS-Nummer: 1801176-81-7
• Molekulargewicht: 319.40
• UNSPSC-Code: 12352106

Eigenschaften

• Form: powder
• Qualitätsniveau: 100
• Eignung der Reaktion: reagent type: linker
• Funktionelle Gruppe: Boc; carboxylic acid
• Lagertemp.: 2-8°C
• SMILES String: O=C(N(CC1)CCC1C2=CC(CC(O)=O)=CC=C2)OC(C)(C)C

Beschreibung

Anwendung

2-(3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Sonstige Hinweise

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Rechtliche Hinweise

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H315,H317,H319,H410
• P-Sätze: P261 - P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable