917397

(2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride

• Synonym(e): Semi-flexible linker for PROTAC^® development
• Empirische Formel (Hill-System): C₁₂H₂₀Cl₂N₂
• CAS-Nummer: 2244085-89-8
• Molekulargewicht: 263.21
• UNSPSC Code: 12352116
• NACRES: NA.22
• MDL number: MFCD29075589

Eigenschaften

• form: powder
• Quality Segment: 100
• reaction suitability: reagent type: linker
• functional group: amine
• storage temp.: 2-8°C
• SMILES string: NCC1=C(C=CC=C1)C2CCNCC2.Cl.Cl
• InChI: 1S/C12H18N2.2ClH/c13-9-11-3-1-2-4-12(11)10-5-7-14-8-6-10;;/h1-4,10,14H,5-9,13H2;2*1H
• InChI key: VBWHHONSCAVPOS-UHFFFAOYSA-N

Beschreibung

Application

(2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable