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Merck

GRIA1

glutamate receptor, ionotropic, AMPA 1

Synonyme:
GLUH1, GLUR1, GLURA, GluA1, HBGR1
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(2890) Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(14799) glutamate receptor, ionotropic, AMPA1 (alpha 1)
  • Rat(50592) glutamate receptor, ionotropic, AMPA 1
  • dog(489168) glutamate receptor, ionotropic, AMPA 1
  • domestic cat(101097621) glutamate receptor, ionotropic, AMPA 1
  • naked mole-rat(101724828) glutamate receptor, ionotropic, AMPA 1
  • domestic guinea pig(100727046) glutamate receptor, ionotropic, AMPA 1
  • sheep(443271) glutamate receptor, ionotropic, AMPA 1
  • Domestic Rabbit(100348217) glutamate receptor, ionotropic, AMPA 1
  • chicken(414893) glutamate receptor, ionotropic, AMPA 1
  • Horse(100060020) glutamate receptor, ionotropic, AMPA 1
  • cow(529618) glutamate receptor, ionotropic, AMPA 1

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Small Molecule - Agonist

Produktnummer
Beschreibung
Spezies
ATPA, solid,
Spezies
human, rat
2,6-Difluoro-4-[2-(phenylsul­fonyl­amino)­ethyl­thio]­phenoxy­acet­amide, ≥98% (HPLC), solid,
Spezies
human
Quisqualinsäure, powder,
Spezies
rat
Cyclothiazid, ,
Spezies
human, rat
N-Methyl-D-Asparaginsäure, ≥98% (TLC), solid,
Spezies
human, rat

Small Molecule - Allosteric Modulator

Produktnummer
Beschreibung
Spezies
CX546, ≥98% (HPLC), solid,
Spezies
human
Piracetam, ,
Spezies
human, rat
Cyclothiazid, ,
Spezies
human, rat
Diazoxid, ,
Spezies
rat, mouse, human
Kainic acid monohydrate, ≥99% (TLC),
Spezies
human, mouse, rat

Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
2,3-Pyridindicarboxylsäure, 99%,
Spezies
rat
2,3-Dihydroxychinoxalin, 98%,
Spezies
rat
GYKI 52466 hydrochloride, solid,
Spezies
human
ATPA, solid,
Spezies
human, rat
Piracetam, ,
Spezies
human, rat

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-Glutamatrezeptor-1-Antikörper, from rabbit, purified by affinity chromatography,
Speziesreaktivität
equine, horse, human, mouse, platypus, rat
Anwendung
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-GluR1 Antibody, clone C3T, rabbit monoclonal, culture supernatant, clone C3T, Upstate®,
Speziesreaktivität
chimpanzee, human, mouse, rat
Anwendung
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-Pan-AMPA-Rezeptor-Antikörper (GluR1–4), Klon 2D8, clone 2D8, from mouse,
Speziesreaktivität
human, rat
Anwendung
ELISA
electron microscopy

immunocytochemistry

immunofluorescence

immunohistochemistry

western blot
Anti-GluR1-NT(-NT)-Antikörper, Klon RH95, clone RH95, from mouse,
Speziesreaktivität
rat
Anwendung
ELISA
immunocytochemistry

immunoprecipitation (IP)

western blot
Anti-phospho-GluR1(Ser831)-Antikörper, Klon N453, Kaninchen, monoklonal, culture supernatant, clone N453, Upstate®,
Speziesreaktivität
chicken, human, mouse, rat
Anwendung
western blot

Small Molecule - Blocker

Produktnummer
Beschreibung
Spezies
Cyclothiazid, ,
Spezies
human, rat
Kynurensäure, ≥98%,
Spezies
rat, human
Topiramat, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
Topiramat, Pharmaceutical Secondary Standard; Certified Reference Material,
Spezies
human
Topiramate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Spezies
human

Small Molecule - Ligand

Produktnummer
Beschreibung
Spezies
Quisqualinsäure, powder,
Spezies
rat
2-Brom-2-chlor-1,1,1-trifluorethan, ≥99%,
Spezies
human

Small Molecule - Mixed Agonist/Antagonist

Produktnummer
Beschreibung
Spezies
ATPA, solid,
Spezies
human, rat
Cyclothiazid, ,
Spezies
human, rat
(±)-AMPA, solid,
Spezies
rat
Kainic acid monohydrate, ≥99% (TLC),
Spezies
human, mouse, rat
L-Glutaminsäure, ReagentPlus®, ≥99% (HPLC),
Spezies
rat, human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human GRIA1,
Spezies
human