Q2128

Quisqualinsäure

L-glutamate agonist, powder

• Synonym(e): 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanin
• Empirische Formel (Hill-System): C₅H₇N₃O₅
• CAS-Nummer: 52809-07-1
• Molekulargewicht: 189.13
• NACRES: NA.32
• PubChem Substance ID: 24278004
• UNSPSC Code: 12352106
• MDL number: MFCD00069337
• Beilstein/REAXYS Number: 1078734

Eigenschaften

• Produktname: Quisqualinsäure, powder
• form: powder
• Quality Segment: 200
• color: white to off-white
• solubility: ethanol: <0.17 mg/mL, H₂O: 0.5 mg/mL, 0.1 M HCl: 1.4 mg/mL, 1 M NH4OH: 20 mg/mL, organic solvents: insoluble
• storage temp.: 2-8°C
• SMILES string: N[C@@H](CN1OC(=O)NC1=O)C(O)=O
• InChI: 1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
• InChI key: ASNFTDCKZKHJSW-REOHCLBHSA-N
• Gene Information: rat ... Gria1(50592), Grik1(29559), Grin2a(24409), Grm1(24414), Grm2(24415), Grm4(24417), Grm5(24418)

Beschreibung

General description

Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.

Application

Quisqualic acid has also been used as a group I metabotropic receptor agonist in neurons.

Quisqualic acid has been used to test ligand-gated receptors in spiral ganglion neurons.

Biochem/physiol Actions

Active enantiomer of quisqualic acid; excitatory amino acid at glutamate receptors.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves