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P4406

Sigma-Aldrich

Papain Agarose from papaya latex

lyophilized powder, 90-150 units/mL packed gel

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About This Item

MDL號碼:
分類程式碼代碼:
12352204
NACRES:
NA.54
暫時無法取得訂價和供貨情況

生物源

papaya (latex)

品質等級

形狀

lyophilized powder

比活性

90-150 units/mL packed gel

分子量

21 kDa

標籤範圍

3,000-5,000 units per g agarose (at pH7.0 at 30 °C.)

基質

beaded agarose

儲存溫度

−20°C

相關類別

應用

Papain is used in dissecting solutions. It is used to produce Fab fragments of antibodies.[1] It is used for cell dissociation since it has been shown to be more effective and less damaging with certain tissues. Papain has been used to isolate morphologically intact cortical neurons from postnatal rats. Limited papain digestion is used for structural studies of enzymes and other proteins. In addition, papain is used in red cell serology to modify the red cell surface to enhance or destroy the reactivity of many red cell antigens. Papain is useful for platelet serology studies. Papain has also been used in the enzymatic synthesis of amino acids, peptides, and other molecules. Product P4406 is agarose-linked papain and is provided as a lyophilized powder stabilized with lactose. Product P4406 has been used to digest purified anti-JMJD6 hamster monoclonal antibody into Fab fragments[2].
Used to produce Fab fragments of antibodies. Also used for cell dissociation since it has been shown to be more effective and less damaging with certain tissues.

生化/生理作用

A cysteine protease that cleaves peptide bonds of basic amino acids, leucine or glycine. pH optimum 6.0-7.0
Also hydrolyzes esters and amides.
Papain papaya latex has antifungal activity against C. albicans. It is a cysteine protease that cleaves peptide bonds of basic amino acids, leucine, or glycine.
. The pH optimum is 6.0-7.0
. Papain hydrolyzes esters and amides. Papain consists of a single polypeptide chain with three disulfide bridges and a sulfhydryl group necessary for activity of the enzyme.

單位定義

One unit will hydrolyze 1.0 μmole of BAEE per min at pH 6.2 at 25°C, unless otherwise indicated below.

外觀

Lyophilized powder, stabilized with lactose

象形圖

Health hazard

訊號詞

Danger

危險聲明

危險分類

Resp. Sens. 1 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Yafei Liu et al.
Cell, 184(13), 3452-3466 (2021-06-18)
Antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein prevent SARS-CoV-2 infection. However, the effects of antibodies against other spike protein domains are largely unknown. Here, we screened a series of anti-spike monoclonal antibodies from coronavirus disease 2019
Xia Hong et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(33), 14568-14572 (2010-08-04)
JMJD6 is a Jumonji C domain-containing hydroxylase. JMJD6 binds alpha-ketoglutarate and iron and has been characterized as either a histone arginine demethylase or U2AF65 lysyl hydroxylase. Here, we describe the structures of JMJD6 with and without alpha-ketoglutarate, which revealed a
Y. Ozari et al.
Journal of the Chemical Society. Chemical Communications, 295-295 (1974)

文章

Uncover properties and applications of the cysteine protease papain and find inhibitors, substrates, and other papain products.

發現半胱氨酸蛋白酶木瓜蛋白酶的特性和應用,並找到抑制劑、底物和其他木瓜蛋白酶產品。

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