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文件

L2023

Sigma-Aldrich

亮肽素 三氟乙酸盐

powder, ≥90% (HPLC)

同義詞:

Acetyl-Leu-Leu-Arg-al 三氟乙酸盐

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About This Item

經驗公式（希爾表示法）:
C20H38N6O4 · xC2HF3O2
CAS號碼:
147385-61-3
分子量：:
426.55 (free base basis)
MDL號碼:
MFCD00133458
分類程式碼代碼:
12352202
PubChem物質ID:
329817397
NACRES:
NA.77

product name

亮肽素 三氟乙酸盐, ≥90% (HPLC), microbial

生物源

microbial

品質等級

200

化驗

≥90% (HPLC)

形狀

powder

溶解度

H2O: 10 mM (Solutions are stable only a few hours. Stock solutions are stable up to 6 months at −20 °C.)

儲存溫度

−20°C

SMILES 字串

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O

InChI

1S/C20H38N6O4.C2HF3O2/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;3-2(4,5)1(6)7/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H,6,7)/t15-,16-,17-;/m0./s1

InChI 密鑰

WUHGBZVQELGOMH-FRKSIBALSA-N

生化／生理作用

丝氨酸和半胱氨酸蛋白酶抑制剂。抑制纤溶酶、胰蛋白酶、木瓜蛋白酶、钙蛋白酶和组织蛋白酶B。不抑制胃蛋白酶、组织蛋白酶A和D、凝血酶或α-糜蛋白酶。有效浓度为10-100 μM。已有许多研究使用亮抑酶肽来预防因听觉过度刺激或耳毒性抗生素庆大霉素引起的听力损失。(耳蜗毛细胞的丧失被认为是由钙蛋白酶介导的。)

分析報告

由于在溶液中形成互变异构异构体，亮抑酶肽在 HPLC 上产生多个峰。大多数污染肽是外消旋亮抑酶肽。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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