T1270

Thiamine hydrochloride

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

• Synonim(y): Aneurine hydrochloride, Vitamin B₁ hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₂H₁₇ClN₄OS · HCl
• Numer CAS: 67-03-8
• Masa cząsteczkowa: 337.27
• Beilstein: 3851771
• Numer WE: 200-641-8
• Numer MDL: MFCD00012780
• Kod UNSPSC: 12352207
• eCl@ss: 34058006
• Identyfikator substancji w PubChem: 24899952
• NACRES: NA.75

Właściwości

• pochodzenie biologiczne: synthetic (organic)
• linia produktu: BioReagent
• Próba: ≥99.0% (HPLC)
• Formularz: powder
• masa cząsteczkowa: M_w 337.27 g/mol
• metody: cell culture | insect: suitable; cell culture | mammalian: suitable; cell culture | plant: suitable
• kolor: white
• mp: 250 °C (dec.) (lit.)
• rozpuszczalność: H₂O: 50 mg/mL, clear, colorless
• Zastosowanie: agriculture
• ciąg SMILES: CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]
• InChI: 1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1
• Klucz InChI: DPJRMOMPQZCRJU-UHFFFAOYSA-M

Opis

Opis ogólny

Thiamine or Vitamin B1 is a positively charged and essential constituent for all tissues. It is present at higher levels in skeletal muscles, liver, kidney, heart, and brain.[1] Thiamine is composed of a pyrimidine ring linked to a thiazole ring via a methylene bridge. [2]

Zastosowanie

Thiamine hydrochloride has been used as a component:

• of the vitamin-concentrated stock solution for the preparation of Hv-Ca medium for culturing Haloferax volcanii[3]
• of the tris-acetate-phosphate (TAP) medium for culturing Chlamydomonas nivalis[4]
• of modified Bold 3N medium for culturing Chlorella minutissima[5]

Działania biochem./fizjol.

Thiamine is converted to thiamine diphosphate post-movement into the cellular membranes by thiamine diphosphokinase.[1] Thiamine diphosphate, an active cofactor is essential for the mechanism of many enzymes involved in the citric acid cycle, the glycolytic pathway, the degradation of branched-chain amino acids, and the pentose phosphate pathway.[6] Thiamine is involved in converting food into energy required for functioning the central and peripheral nervous systems. Lower levels of this vitamin are associated with delirium, Wernicke′s encephalopathy, and Wernicke-Korsakoff syndrome.[7] Thiamine hydrochloride is required to support energy metabolism and amino acid synthesis in cultured cells. It is present in many classical and serum-free formulations.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H319
• Zwroty wskazujące środki ostrożności: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Klasyfikacja zagrożeń: Eye Irrit. 2
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)