S8559

Sinefungin

95% (HPLC), powder, methylation of bases in DNA & RNA inhibitor

• Synonim(y): 5′-Deoxy-5′-(1,4-diamino-4-carboxybutyl)adenosine, A-9145, Adenosylornithine, Antibiotic 32232RP
• Wzór empiryczny (zapis Hilla): C₁₅H₂₃N₇O₅
• Numer CAS: 58944-73-3
• Masa cząsteczkowa: 381.39
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24899800
• NACRES: NA.77

Właściwości

• Nazwa produktu: Sinefungin, 95% (HPLC), powder
• Poziom jakości: 200
• Próba: 95% (HPLC)
• Formularz: powder
• kolor: white to yellow
• rozpuszczalność: H₂O: complete 20 mg/ml, clear, colorless to light yellow; H₂O: soluble
• spektrum działania antybiotyku: neoplastics
• Tryb działania: DNA synthesis | interferes; enzyme | inhibits
• temp. przechowywania: 2-8°C
• ciąg SMILES: N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
• InChI: 1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1
• Klucz InChI: LMXOHSDXUQEUSF-YECHIGJVSA-N

Opis

Opis ogólny

Chemical structure: nucleoside

Zastosowanie

Sinefungin was used to inhibit global methyltransferases in breast cancer cell line, MCF7² and Jurkat cells.³ It was used as S-adenosylmethionine analogue in equilibrium FRET experiments.⁴

Działania biochem./fizjol.

Blocks the methylation of bases in DNA and RNA; involved in physiological processes such as aging and carcinogenesis.

Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N⁶-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis.

Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N⁶-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis.
Methylation inhibition by sinefugin is often accompanied by an altered rate of cytosine deamination that is coupled to transition mutation in the DNA. Sinefugin inhibits Epstein-Barr viral activity and this inhibition is related to the change in DNA methylation and gene expression. It can cause a rate change in several restriction DNA endonuclease activities, including Mme I, which is not connected to the inhibition of the methytransferase activity.

Cechy i korzyści

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Gloves