C6022

Cyproheptadine hydrochloride sesquihydrate

≥98% (TLC), solid

• Synonim(y): Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride, hydrate (2:3)
• Wzór empiryczny (zapis Hilla): C₂₁H₂₁N·HCl·1.5H₂O
• Numer CAS: 41354-29-4
• Masa cząsteczkowa: 350.88
• Numer WE: 213-535-1
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24278082
• NACRES: NA.77

Właściwości

• Próba: ≥98% (TLC)
• Postać: solid
• kolor: white to slightly yellow
• rozpuszczalność: ethanol: soluble; methanol: soluble
• inicjator: Merck & Co., Inc., Kenilworth, NJ, U.S.
• ciąg SMILES: Cl.CN1CCC(\CC1)=C2/c3ccccc3C=Cc4ccccc24
• InChI: 1S/2C21H21N.2ClH.3H2O/c2*1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;;;;/h2*2-11H,12-15H2,1H3;2*1H;3*1H2
• Klucz InChI: ZEAUHIZSRUAMQG-UHFFFAOYSA-N
• informacje o genach: human ... HRH1(3269) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

Opis

Zastosowanie

Cyproheptadine hydrochloride sesquihydrate has been used in:

• testing anti-inflammatory activity in serotonin receptor (5-HT) induced inflammation
• the inhibition of 5-HT in in vivo and in vitro bioassays in crabs
• the inhibition of 5-HT in embryo physiological experiments

inhibition of calcitonin gene related peptide (CGRP)

Działania biochem./fizjol.

Cyproheptadine hydrochloride sesquihydrate is a serotonin receptor (5-HT2/5-HT1C) antagonist, H1 histamine receptor antagonist and an antipruritic. The inhibition of 5-HT by cyproheptadine improves cognitive function in schizophrenia disorder. Cyproheptadine is effective for treating functional gastrointestinal disorders (FGIDs). Food and Drug Administration (FDA) approved cyproheptadine, has antidepressant and antiplatelet functionality. It may be effective in treating thromboembolic disorders. Cyproheptadine inhibits lysine methyltransferase 7/9 (Set7/9) leading to a decrease in estrogen receptor (ERα) expression and growth arrest in breast cancer cells.

Cechy i korzyści

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H301,H315,H319,H335
• Zwroty wskazujące środki ostrożności: P261 - P264 - P271 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Środki ochrony indywidualnej: dust mask type N95 (US), Eyeshields, Faceshields, Gloves