This material is not a fat-soluble molecule. The product is water soluble at 100 mg/mL.
A7007
S-(5′-Adenosyl)-L-methionine chloride dihydrochloride
≥75%
Synonim(y):
SAM, Active methionine, AdoMet, SAM chloride dihydrochloride
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Wybierz wielkość
25 MG
454,00 zł
5 MG
625,00 zł
100 MG
1090,00 zł
500 MG
3410,00 zł
1 G
5650,00 zł
454,00 zł
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Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C15H23ClN6O5S · 2 HCl
Numer CAS:
Masa cząsteczkowa:
507.82
UNSPSC Code:
12352209
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
6560002
Form:
powder
Assay:
≥75%
Solubility:
H2O: 100 mg/mL
Biological source:
synthetic (chemical)
Color:
white to off-white
Przejdź do
Pomoc techniczna
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Pozwól nam pomócInChI
1S/C15H22N6O5S.3ClH/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;;;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);3*1H/t7-,8+,10+,11+,14+,27?;;;/m0.../s1
SMILES string
Cl.Cl.[Cl-].C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
InChI key
KBAFOJZCBYWKPU-XQVUROGGSA-N
biological source
synthetic (chemical)
assay
≥75%
form
powder
color
white to off-white
solubility
H2O: 100 mg/mL
application(s)
cell analysis
shipped in
dry ice
storage temp.
−20°C
Quality Level
1 of 4
Ta pozycja | |||
|---|---|---|---|
| solubility H2O: 100 mg/mL | solubility H2O: 100 mg/mL | solubility - | solubility 1 M HCl: soluble 19.60-20.40 mg/mL, clear to slightly hazy, colorless to faintly yellow |
| assay ≥75% | assay ≥80% (HPLC), ≥80% (spectrophotometric assay) | assay ≥90% (CP) | assay ≥98.0% (HPLC), ≥98.0% (TLC) |
| biological source synthetic (chemical) | biological source synthetic (Organic) | biological source - | biological source - |
| Quality Level 300 | Quality Level 300 | Quality Level 200 | Quality Level 300 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| form powder | form powder | form solid | form crystalline |
General description
S-(5′-Adenosyl)-L-methionine chloride dihydrochloride (SAM) facilitates the transfer of methyl groups to proteins, lipids and nucleic acids. Methionine adenosyl transferase catalyses the synthesis of SAM from methionine and adenosine triphosphate (ATP). SAM functions to regulate various cellular functions like cell division, cell death, transcription, genetic stability, oxidant/antioxidant balance and polyamine homeostasis. Therapeutically, SAM finds its application as a nutritional supplement in humans for various diseases like osteoarthritis and liver injury. SAM also regulates transsulfuration reactions by binding to the regulatory domain of key enzyme cystathionine-β-synthase (CBS).[1]
Application
S-(5′-Adenosyl)-L-methionine chloride dihydrochloride has been used as a medium supplement for S30 cell extract.[2] It also has been used for measuring the interaction with catechol-O-methyltransferase (COMT) by quartz crystal microbalance (QCM), surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) with supported lipid bilayers and vesicles.[3]
Biochem/physiol Actions
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT).
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
Analysis Note
Purity based on UV and HPLC.
Disclaimer
This material is 80-90% pure when prepared, but is very unstable. As much as 10% purity loss per day at 25 °C has been noted.
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Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Membrane bound COMT isoform is an interfacial enzyme: general mechanism and new drug design paradigm
Magarkar A, et al.
Chemical Communications (Cambridge, England), 54(28), 3440-3443 (2018)
Andria V Rodrigues et al.
Chembiochem : a European journal of chemical biology, 21(5), 663-671 (2019-09-13)
We recently reported the discovery of phenylacetate decarboxylase (PhdB), representing one of only ten glycyl-radical-enzyme reaction types known, and a promising biotechnological tool for first-time biochemical synthesis of toluene from renewable resources. Here, we used experimental and computational data to
Chemical communication between bacteria and cell-free gene expression systems within linear chains of emulsion droplets
Schwarz-Schilling M, et al.
Integrative Biology : Quantitative Biosciences from Nano to Macro, 8(4), 564-570 (2016)
Yan Zhang et al.
Archives of microbiology, 191(10), 773-783 (2009-09-05)
Enolase-phosphatase (E1), as an enzyme, is involved in methionine salvage pathway in many prokaryotic and eukaryotic organisms. But the identity and function of E1 in Xanthomonas oryzae pv. oryzae (Xoo) remain undetermined. Here, we report the cloning and characterization of
Ted M Lakowski et al.
Analytical biochemistry, 396(1), 158-160 (2009-09-08)
S-Adenosyl-L-homocysteine (AdoHcy) background signal in reactions with protein arginine N-methyltransferase 1 is investigated using an ultrahigh-performance liquid chromatography tandem mass spectrometry assay that measures AdoHcy. We identify three sources of AdoHcy background: enzymatic automethylation, AdoHcy contamination in commercial S-adenosyl-L-methionine (AdoMet)
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