This product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals. Currently, there is no available product suitable for human use.
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Kluczowe dokumenty
P9386
Poly-L-histidine
mol wt 5,000-25,000
Synonim(y):
Homopolimer L-histydyny
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10 MG
670,00 zł
50 MG
1850,00 zł
100 MG
3350,00 zł
670,00 zł
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10 MG
670,00 zł
50 MG
1850,00 zł
100 MG
3350,00 zł
About This Item
Numer CAS:
Numer MDL:
Kod UNSPSC:
12352209
Identyfikator substancji w PubChem:
NACRES:
NA.26
670,00 zł
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Poproś o zamówienie zbiorcze
Polecane produkty
Formularz
powder or solid
masa cząsteczkowa
5,000-25,000
kolor
white to light yellow
Zastosowanie
cell analysis
temp. przechowywania
−20°C
ciąg SMILES
[N+H3][C@@H](Cc1[nH]cnc1)C(=O)[O-]
InChI
1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
Klucz InChI
HNDVDQJCIGZPNO-YFKPBYRVSA-N
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Opis ogólny
Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation−deprotonation.[1]
Zastosowanie
Działania biochem./fizjol.
Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)−poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin.[5] pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment.[6]
Komentarz do analizy
Molecular weight by MALLS.
Inne uwagi
For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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Certyfikaty analizy (CoA)
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The efficacy of protein-based medicines can be compromised by their rapid clearance from the blood circulatory system. Achieving optimal pharmacokinetics is a key requirement for the successful development of safe protein-based medicines. Protein PEGylation is a clinically proven strategy to
Shoichiro Asayama et al.
Bioconjugate chemistry, 23(7), 1437-1442 (2012-06-12)
Poly(L-histidine) (PLH) with dimethylimidazole groups has been synthesized as a pH-sensitive polypeptide to control the stability of its small interfering RNA (siRNA) polyion complexes for RNA interference (RNAi). The resulting methylated PLH (PLH-Me) was water-soluble despite deprotonation of the imidazole
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Produkty
Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.
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Is this an oral product and if so, what is the recommended dose? If not, how is this product used?
1 answer-
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Hello, I am interested in your product Poly-L-histidine (P9386). Could you please confirm what terminal groups are present at both the N- and C-termini of this polymer?
1 answer-
This polymer has carboxyl and amino end groups. Further detailed studies have not been conducted.
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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What is this product's pKa?
1 answer-
The pKa value is not determined.
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