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P5660

Sigma-Aldrich

3-sn-Phosphatidyl-L-serine sodium salt from bovine brain

≥95% (TLC)

Synonim(y):

1,2-Diacyl-sn-glycero-3-phospho-L-serine, L-α-Phosphatidyl-L-serine sodium salt

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Wybierz wielkość

5 MG
1770,00 zł
25 MG
7050,00 zł
100 MG
13 209,00 zł

1770,00 zł

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Wszystkie zdjęcia(2)

Wybierz wielkość

Zmień widok
5 MG
1770,00 zł
25 MG
7050,00 zł
100 MG
13 209,00 zł

About This Item

Numer MDL:
MFCD00077390
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
24898688
NACRES:
NA.77

1770,00 zł

Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Poproś o zamówienie zbiorcze

Próba

≥95% (TLC)

Formularz

powder

temp. przechowywania

−20°C

ciąg SMILES

[Na+].CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C([O-])=O)OC(=O)CCCCCCCCCCCCCCCCC

InChI

1S/C42H82NO10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(44)50-35-38(36-51-54(48,49)52-37-39(43)42(46)47)53-41(45)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h38-39H,3-37,43H2,1-2H3,(H,46,47)(H,48,49);/q;+1/p-1/t38-,39+;/m1./s1

Klucz InChI

SJRBMGBLPUBGJL-MBAWARMDSA-M

Opis ogólny

Phosphatidylserine is an anionic phospholipid, which is found on the plasma membrane.[1] Exposure of phosphatidylserine on the surface of plasma membrane stimulates the removal of apoptotic and red blood cells.[2] It regulates the production of thrombin and maintains hemostasis.[3]

Zastosowanie

3-sn-Phosphatidyl-L-serine sodium salt from bovine brain has been used as a glycosylphosphatidylinositol (GPI)-anchor control.[3]

Działania biochem./fizjol.

A slowly metabolized structural phospholipid found mainly in gray matter.

Przestroga

Solutions exposed to room temperature will decompose about 0.5% per day.

Uwaga dotycząca przygotowania

Washed with EDTA and converted to a sodium salt.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
0000406085
0000406085
0000384656
0000384656
SLCJ5459

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression
Fadeel B, et al.
Biochemical and Biophysical Research Communications, 266(2), 504-511 (1999)
The role of phosphatidylserine in recognition and removal of erythrocytes.
Kuypers FD
Cellular and molecular biology (Noisy-le-Grand, France), 50(2), 147-158 (2004)
Exposure of platelet membrane phosphatidylserine regulates blood coagulation
Lentz BR
Progress in Lipid Research, 42(5), 423-438 (2003)
TIMP-1-GPI in combination with hyperthermic treatment of melanoma increases sensitivity to FAS-mediated apoptosis
Djafarzadeh R, et al.
Cancer Immunology, Immunotherapy, 58(3), 361-361 (2009)
Julien Perino et al.
Antiviral research, 89(1), 89-97 (2010-11-26)
Vaccinia virus (VACV) was used as a surrogate of Variola virus (genus Orthopoxvirus), the causative agent of smallpox, to study orthopoxvirus infection via the respiratory airway. Lung surfactant, a physiological barrier to infection encountered by the virus, is predominantly composed
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Questions

1–7 of 7 Questions  

  1. What is Product P5660, 3-sn-Phosphatidyl-L-serine sodium salt, commonly used for?

    1 answer

    1. Phosphatidylserine is important in enzymatic assays of purified protein kinase C. During activation of this enzyme, as part of the signal transduction process, phosphatidylserine, which is located on the inside of cellular plasma membranes, binds to cysteine residue domains on protein kinase C. Phosphatidylserine can be used as a standard in thin-layer chromatography and for artificial membrane studies such as in lipsome research.

      Helpful?

  2. Is 3-sn-Phosphatidyl-L-serine sodium salt from bovine brain available in solution?

    1 answer

    1. Yes. Product No. P6641 is a ready-to-use solution of phosphatidylserine in a chloroform:methanol mixture.

      Helpful?

  3. Do you have any inhibitors for Protein Kinase C (PKC)?

    1 answer

    1. Yes. Two examples are Product No. C6303 (Calphostin C from Cladosporium cladosporioides) and Product No. C2932 (Chelerythrine chloride).

      Helpful?

  4. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  5. What is the molecular weight of Product P5660, 3-sn-Phosphatidyl-L-serine sodium salt from bovine brain?

    1 answer

    1. The molecular weight of this compound is approximately 812.1 g/mole. This molecular weight assumes that stearoyl and oleoyl are the prodimant fatty acids in the compound.  Phosphatidylserine may have a number of different fatty acid residues associated with it.  Our analyses of multiple lots of phosphatidylserine identified average fatty acid percentages of approximately 40% for stearic acid and 30% for oleic acid.

      Helpful?

  6. What is Product P5660, 3-sn-Phosphatidyl-L-serine sodium salt from bovine brain, soluble in?

    1 answer

    1. This product is soluble in chloroform:methanol (95:5 v/v) at a concentration of 50 mg/mL. It will likely form a suspension or emulsion in deionized water at a concentration of 1 mg/mL or higher.

      Helpful?

  7. What is the solution stability of Product P5660, 3-sn-Phosphatidyl-L-serine sodium salt from bovine brain?

    1 answer

    1. Solutions can be divided into aliquots and stored at -20 °C. We have no information as to how long the solutions will be stable. Solution stability is enhanced when the compound is protected from oxygen, because the unsaturated fatty acids are subject to oxidation. To protect from oxidation, dissolve the compound in solvents in which oxygen has been removed and replaced with an inert gas such as nitrogen or argon.

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