M2537

Mevastatin

≥98% (HPLC), powder or crystals

• Synonim(y): Compactin, ML-236B
• Wzór empiryczny (zapis Hilla): C₂₃H₃₄O₅
• Numer CAS: 73573-88-3
• Masa cząsteczkowa: 390.51
• Beilstein: 1269441
• Numer MDL: MFCD05662341
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24278540
• NACRES: NA.77

Właściwości

• Próba: ≥98% (HPLC)
• Formularz: powder or crystals
• kolor: white to light yellow
• mp: 151 °C
• rozpuszczalność: ethanol: 25-26 mg/mL, clear, colorless
• spektrum działania antybiotyku: neoplastics
• Tryb działania: enzyme | inhibits
• inicjator: Daiichi-Sankyo
• temp. przechowywania: 2-8°C
• ciąg SMILES: [H][C@]12[C@H](CCC=C1C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)OC(=O)[C@@H](C)CC
• InChI: 1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
• Klucz InChI: AJLFOPYRIVGYMJ-INTXDZFKSA-N
• informacje o genach: human ... HMGCL(3155) , HMGCR(3156) ; rat ... Hmgcr(25675)

Opis

Opis ogólny

Chemical structure: statin

Mevastatin is a polyketide that belongs to the class of statins. It contains a hydroxy-hexahydronaphthalene ring.[1]

Zastosowanie

Mevastatin has been used:

• to analyze its effects on chronic lymphocytic leukemia (CLL) cells by cytotoxic assay[2]
• as a prenylation inhibitor to analyze its effects on human embryonic kidney (HEK) cells transfected with K-Ras[3]
• as a statin agent to study its anti-cancer effect on human breast cancer cells and glioblastoma in vitro[4]

Działania biochem./fizjol.

Mevastatin is a selective inhibitor of 3-hydroxy 3-methyl glutaryl coenzyme(A) reductase (HMG-CoA reductase), a major enzyme involved in cholesterol synthesis. It acts as a cholesterol-lowering agent. Mevastatin is obtained from various species of fungi.[1] It acts as an antiresorptive agent and has therapeutic effects to treat osteoporosis. Mevastatin inhibits bone resorption by triggering osteoclast apoptosis. It is also involved in the inhibition of prenylation of proteins such as Ras.[5] Mevastatin increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels by blocking the geranylgeranylation of transcription factor Rho.[6]

Cechy i korzyści

This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Opakowanie

Bottomless glass bottle. Contents are inside inserted fused cone.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)