SML0038

Fluvastatin sodium hydrate

≥98% (HPLC)

• Synonim(y): (±)-(3R^*,5S^*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate
• Wzór empiryczny (zapis Hilla): C₂₄H₂₅FNO₄ · Na · xH₂O
• Numer CAS: 93957-55-2
• Masa cząsteczkowa: 433.45 (anhydrous basis)
• Numer MDL: MFCD20488050
• Kod UNSPSC: 12352204
• Identyfikator substancji w PubChem: 329825108
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Formularz: powder
• warunki przechowywania: desiccated
• kolor: white to tan
• rozpuszczalność: H₂O: ≥9 mg/mL
• inicjator: Novartis
• temp. przechowywania: 2-8°C
• ciąg SMILES: O.[Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13
• InChI: 1S/C24H26FNO4.Na.H2O/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);;1H2/q;+1;/p-1/b12-11+;;/t18-,19-;;/m1../s1
• Klucz InChI: KKEMYLLTGGQWCE-PMRANXHDSA-M

Opis

Zastosowanie

Fluvastatin sodium hydrate has been used:

• to examine its effect on β -glucan-induced training on immunity[1]
• to investigate the effect of statins on the number of uncoupling protein 1 (UCP1)⁺ cells[2]
• to determine its effect on insulin degrading enzyme (IDE) secretion from astrocytes[3]
• to treat and study its effect on human umbilical vein endothelial cells (HUVECs) in vitro[4]

Fluvastatin sodium hydrate has been used:

• to test its anti-hepatitis C virus (HCV) activity[5]
• as a cholesterol inhibitor[6]
• to study its effects on β-glucan-induced monocyte immune training[1]

Działania biochem./fizjol.

Fluvastatin has antifungal activity.[7]

Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

Cechy i korzyści

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable