L1381
L-α-Lysophosphatidylcholine from bovine brain
≥99%, Type V
Synonim(y):
1-Acyl-sn-glycero-3-phosphocholine, L-α-Lysolecithin
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About This Item
Polecane produkty
opis
zwitterionic
typ
Type V
Próba
≥99%
typ lipidu
phospholipids
temp. przechowywania
−20°C
Opis ogólny
Zastosowanie
L-α-Lysophosphatidylcholine from bovine brain has been used:
- to determine the dose-dependent high-mobility group box 1 (HMGB1) release in macrophage and monocyte cultures by production of lysophosphatidylcholine (LPC)[3]
- for lysolecithin demyelination of mice brain tissue[4]
- for demyelination of axons[5]
Działania biochem./fizjol.
L-α-Lysophosphatidylcholine possess cytotoxic effects and is present at high level in ischemia and atherosclerotic aortas.[2]
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis.
Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is a degradation product of phosphatidylcholine by phospholipase A and has cytolytic properties. The product is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.
Cechy i korzyści
This compound is featured on the Phospholipase D page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Inne uwagi
Contains primarily palmitic, stearic and oleic acids.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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Myelin regulatory factor drives remyelination in multiple sclerosis
Duncan GJ, et al.
Acta neuropathologica, 134(3), 403-422 (2017)
Characterization of plasma unsaturated lysophosphatidylcholines in human and rat
CROSET M, et al.
The Biochemical Journal, 345(1), 61-67 (2000)
Yuan Wang et al.
Oncotarget, 7(32), 50937-50951 (2016-07-30)
The earlier study showed that lysophosphatidylcholine (lysoPC) induced apoptosis in human coronary artery smooth muscle cells (SMCs); however, the related molecular mechanisms are not fully understood. The present study investigated how lysoPC induces apoptosis in cultured human coronary artery SMCs
Metabolism and atherogenic disease association of lysophosphatidylcholine
Schmitz G and Ruebsaamen K
Atherosclerosis, 208(1), 10-18 (2010)
Human induced pluripotent stem cells differentiation into oligodendrocyte progenitors and transplantation in a rat model of optic chiasm demyelination
Pouya A, et al.
PLoS ONE, 6(11), e27925-e27925 (2011)
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