This product is not GMP grade. Unfortunately, a GMP grade α-Ketoglutaric acid product is not currently offered. This product is intended for research use only. Unless otherwise stated this product is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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K1128
α-Ketoglutaric acid
BioReagent, suitable for cell culture, suitable for insect cell culture
Synonim(y):
2-Oxoglutaric acid, 2-Oxopentanedioic acid
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 5 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 237,00 zł | |
| 25 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 317,00 zł | |
| 100 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1020,00 zł |
Informacje o tej pozycji
Wzór liniowy:
HOOCCH2CH2COCOOH
Numer CAS:
Masa cząsteczkowa:
146.10
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
EC Number:
206-330-3
Beilstein/REAXYS Number:
1705689
MDL number:
237,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócproduct line
BioReagent
Quality Segment
assay
≥98.5% NaOH basis (titration)
form
powder or crystals
technique(s)
cell culture | insect: suitable, cell culture | mammalian: suitable
solubility
water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless
storage temp.
2-8°C
SMILES string
OC(=O)CCC(=O)C(O)=O
InChI
1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChI key
KPGXRSRHYNQIFN-UHFFFAOYSA-N
General description
Alpha-ketoglutarate (αKG), a vital intermediate in the tricarboxylic acid (TCA)/Krebs cycle, is located between succinyl-CoA and isocitrate.[1]
Application
α-Ketoglutaric acid has been used:
- as a supplement in minimum essential medium α (α-MEM) to culture primary mesenchymal stromal/stem cells (MSCs) to study its effects on age-related osteoporosis[1]
- for chemical treatments to compare the treatment effects of several compounds on lifespan between manual and automated lifespan machine (ALM) platforms[2]
- as a printed chemotaxis ligand to screen chemotaxis receptors with high-throughput technologies and verify the interactions with surface plasmon resonance (SPR)[3]
Biochem/physiol Actions
Alpha-ketoglutarate (αKG), a nitrogen scavenger, is an important source of glutamate and glutamine.[4] It controls the synthesis of ATP and decreases the generation of equivalent (NAD+/NADH) in the tricarboxylic acid (TCA) cycle.[1] It promotes the synthesis of protein and prevents protein degradation in muscles. This immune nutrient factor participates in the general immune and collagen metabolism.[4] In aged rodents, αKG accelerates the healing of bone defects. It may possess potential anti-aging effects.[1] This Krebs cycle molecule can be used as a supplement in insect and mammalian cell cultures.
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Ta pozycja | |||
|---|---|---|---|
| assay ≥98.5% NaOH basis (titration) | assay ≥98.5% (NaOH, titration) | assay 99.0-101.0% (T) | assay ≥97% (HPLC) |
| technique(s) cell culture | insect: suitable, cell culture | mammalian: suitable | technique(s) - | technique(s) - | technique(s) cell culture | insect: suitable, cell culture | mammalian: suitable |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
| form powder or crystals | form powder | form crystals | form powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| product line BioReagent | product line - | product line - | product line BioReagent |
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signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| K1128-25G | 04061833867884 |
| K1128-100G | 04061832908755 |
| K1128-5G | 04061833867891 |
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