O7753

Oxaloacetic acid

powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97% (HPLC)

• Synonim(y): 2-Oxosuccinic acid, Ketosuccinic acid, Oxalacetic acid, Oxobutanedioic acid
• Wzór liniowy: HOOCCH₂COCOOH
• Numer CAS: 328-42-7
• Masa cząsteczkowa: 132.07
• UNSPSC Code: 12352204
• NACRES: NA.75
• PubChem Substance ID: 24898047
• EC Number: 206-329-8
• Beilstein/REAXYS Number: 1705475
• MDL number: MFCD00002592

Właściwości

• biological source: synthetic (organic)
• Quality Segment: 200
• product line: BioReagent
• assay: ≥97% (HPLC)
• form: powder
• technique(s): cell culture | insect: suitable, cell culture | mammalian: suitable
• solubility: H₂O: 100 mg/mL
• storage temp.: −20°C
• SMILES string: OC(=O)CC(=O)C(O)=O
• InChI: 1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)
• InChI key: KHPXUQMNIQBQEV-UHFFFAOYSA-N

Opis

General description

Oxaloacetic acid is a dicarboxylic acid that is present in every cell in the body. It is a metabolic intermediate of the tricarboxylic acid (TCA) cycle and gluconeogenesis.

Application

Oxaloacetic acid has been used to evaluate its effect on neuromuscular function and lifespan in amyotrophic lateral sclerosis (ALS) model superoxide dismutase 1 (SOD1) G93A mice. It has also been used as a supplement in Dulbecco′s modified Eagle′s medium (DMEM) to culture chicken fibroblast (DF-1) cells and chemically immortalized leghorn male hepatoma (LMH) cells for functional validation experiments.

Biochem/physiol Actions

Oxaloacetic acid plays a vital role in central metabolism. It inhibits succinate dehydrogenase and is a key regulator of mitochondrial metabolism.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Klasa składowania: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges