Quantitative purity testing is not performed on this product. The minimum activity is 11,500 units per milligram. The maximum allowable related substances is 5.5%. These values vary from lot to lot and are reported in the product Certificate of Analysis. The amount of powder in each vial may be determined by dividing the number of units in a given package size by the lot specific activity results. For example, 10000000 units / 11500 IU per milligram = 869.6 mg per vial. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sigma/c1511#product-documentation
Przejdź do
C1511
Colistin sodium methanesulfonate
~11,500 U/mg
Synonim(y):
Colimycin sodium methanesulfonate, Methanesulfonic acid derivative of Polymyxin E, Polymyxin E sodium methanesulfonate
Zaloguj się, aby wyświetlić ceny organizacyjne i kontraktowe.
Wybierz wielkość
Zmień widok
| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 10000000 units | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1060,00 zł | |
| 100000000 units | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 6490,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C58H115N16Na5O28S5
Numer CAS:
Masa cząsteczkowa:
1759.90
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
232-516-9
MDL number:
1060,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
Potrzebujesz pomocy? Nasz zespół doświadczonych naukowców chętnie Ci pomoże.
Pozwól nam pomócform
powder
Quality Level
specific activity
~11,500 U/mg
solubility
H2O: 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria
mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
[Na+].[Na+].[Na+].[Na+].[Na+].CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CS([O-])(=O)=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)O
InChI
1S/C53H100N16O13.5CH4O3S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;5*1-5(2,3)4;;;;;/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);5*1H3,(H,2,3,4);;;;;/q;;;;;;5*+1/p-5/t30?,31-,32-,33+,34-,35+,36+,37+,38+,39+,40-,42+,43+;;;;;;;;;;/m1........../s1
InChI key
WSDSONZFNWDYGZ-BKFDUBCBSA-I
General description
Chemical structure: peptide
Application
Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination.
Biochem/physiol Actions
Colistin is a cationic, multicomponent lipopeptide antibiotic. It consists of a cyclic heptapeptide with tripeptide side chain, acylated at the N terminus by a fatty acid. It exhibits a potent anti-endotoxin.[1] Colistin interacts with the anionic LPS molecules and displaces calcium and magnesium ions. It solubilzes the cytoplasmic membrane resulting in leakage of cytosol which contributes to the bactericidal effect.[2][1]
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.
Antimicrobial spectrum: Gram-negative bacteria.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
Ta strona może zawierać tekst przetłumaczony maszynowo.
1 of 1
Ta pozycja | |||
|---|---|---|---|
| antibiotic activity spectrum Gram-negative bacteria | antibiotic activity spectrum Gram-negative bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - |
| mode of action cell membrane | interferes | mode of action cell membrane | interferes | mode of action - | mode of action - |
| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level 300 |
| form powder | form powder or crystals | form solid | form - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. -10 to -25°C |
| solubility H2O: 50 mg/mL | solubility - | solubility - | solubility - |
Klasa składowania
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Wybierz jedną z najnowszych wersji:
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Sachin Gupta et al.
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 13(2), 49-53 (2009-11-03)
One of the greatest achievements of modern medicine is the development of antibiotics against life-threatening infections, but the emergence of multidrug-resistant (MDR) gram negative bacteria has drastically narrowed down the therapeutic options against them. This limitation has led clinicians to
Matthew E Falagas et al.
Expert review of anti-infective therapy, 6(5), 593-600 (2008-10-14)
Despite the constantly increasing need for new antimicrobial agents, antibiotic drug discovery and development seem to have greatly decelerated in recent years. Presented with the significant problem of advancing antimicrobial resistance, the global scientific community has attempted to find alternative
Roberto Imberti et al.
Chest, 138(6), 1333-1339 (2010-06-19)
Infections caused by multidrug-resistant gram-negative bacteria have caused a resurgence of interest in colistin. To date, information about pharmacokinetics of colistin is very limited in critically ill patients, and no attempts have been made to evaluate its concentration in BAL.
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| C1511-10MU | 04061833467688 |
| C1511-100MU | 04061833467671 |
-
How I can convert U/mg (specific activity of this product) to mg/mg? Thanks
1 answer-
Helpful?
-