S-Methyl methanethiosulfonate (MMTS) is commonly used to modify and block thiol groups in proteins. To achieve effective blocking of thiol groups with MMTS, the following ranges should be considered:
pH: Reactions with MMTS are typically performed in buffers with a pH range of 7-8.
Temperature: Blocking of Thiols can be carried out at room temperature (25 °C).
A literature search is encouraged to determine the best conditions for specific applications.
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64306
S-Methyl methanethiosulfonate
purum, ≥98.0% (GC)
Synonim(y):
S-Methyl thiomethanesulfonate, MMTS
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 1 mL | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 211,00 zł | |
| 10 mL | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 979,00 zł |
Informacje o tej pozycji
Wzór liniowy:
CH3SO2SCH3
Numer CAS:
Masa cząsteczkowa:
126.20
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
220-970-0
Beilstein/REAXYS Number:
1446059
MDL number:
Assay:
≥98.0% (GC)
211,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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purum
Quality Segment
assay
≥98.0% (GC)
refractive index
n20/D 1.513
bp
69-71 °C/0.4 mmHg (lit.)
solubility
chloroform: 750mg + 5 ml Chloroform mg/mL, colorless to light greenish-yellow
density
1.337 g/mL at 20 °C, 1.337 g/mL at 25 °C (lit.)
functional group
disulfide
storage temp.
2-8°C
SMILES string
CSS(C)(=O)=O
InChI
1S/C2H6O2S2/c1-5-6(2,3)4/h1-2H3
InChI key
XYONNSVDNIRXKZ-UHFFFAOYSA-N
Application
- Modification of Thiol Enzymes: S-methyl methanethiosulfonate (MMTS) offers a unique method for the modification of thiol enzymes and redox-regulated proteins, providing potential applications in biochemical research focused on enzyme regulation and redox biology (Makarov et al., 2019).
- Sensor Development for Protease Activity: S-methyl methanethiosulfonate is used as a blocking reagent on the structural transitions of papain-like cysteine proteases, which supports its utility in sensor development, allowing for the detection and analysis of protease activity in various biological processes (Markovic et al., 2023).
- Agricultural Pathogen Control: Research evaluating S-methyl methanethiosulfonate as a late blight inhibitor highlights its potential as a broad-range toxin against plant pathogens, suggesting applications in agriculture for the management of crop diseases (Joller et al., 2020).
Other Notes
Disclaimer
may discolor to yellow on storage
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Ta pozycja | |||
|---|---|---|---|
| assay ≥98.0% (GC) | assay 97% | assay ≥96.0% (GC) | assay ≥98.0% (HPLC) |
| solubility chloroform: 750mg + 5 ml Chloroform mg/mL, colorless to light greenish-yellow | solubility DMF: soluble 1:1, chloroform: soluble 200 ul per mL, clear, faintly yellow-green, water: soluble 1:5 | solubility - | solubility - |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| density 1.337 g/mL at 20 °C, 1.337 g/mL at 25 °C (lit.) | density 1.337 g/mL at 25 °C (lit.) | density - | density - |
| bp 69-71 °C/0.4 mmHg (lit.) | bp 69-71 °C/0.4 mmHg (lit.) | bp - | bp - |
| refractive index n20/D 1.513 | refractive index n20/D 1.513 (lit.) | refractive index - | refractive index - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Skin Sens. 1
Klasa składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
P. Laszlo et al.
The Journal of Organic Chemistry, 49, 2281-2281 (1984)
D. Scholz
Synthesis, 944-944 (1983)
D J Smith et al.
Biochemistry, 14(4), 766-771 (1975-02-25)
New reagents for the temporary blocking of active or accessible sulfhydryl groups of enzymes have been developed. These reagents, which are either alkyl alkanethiolsulfonates or alkoxycarbonylalkyl disulfides, rapidly and quantitatively place various RS- groups on the sulfhydryls to generate mixed
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| W326305-100G | 04061837528651 |
| 168149-100G | 04061835521173 |
| 168149-500G | 04061835554416 |
| 243005-1KG | 04055977199079 |
| 243005-25GM | 07790788054939 |
| 243005-100GM | 04055977199086 |
| 1028389010 | 04022536692678 |
| 1028380100 | 04022536037370 |
| 1028381000 | 04022536037387 |
| 30089-25G | 04061826660591 |
| 30089-100G | 04061826660096 |
| 30089-1G-KC | 04061826680261 |
| 30089-500G | 04061833440315 |
| W326305-1KG | 04061835566839 |
| C7352-100G | 04061835568321 |
| C7352-25G | 04061835568338 |
| 778672-25KG | 04061833367568 |
| 778672-100G | 04061833315064 |
| C5360-25KG | 04061834413837 |
| C5360-10KG | 04061834413813 |
| C5360-100G | 04061833502013 |
| W326305-5KG | 04061834397441 |
| W326305-SAMPLE | 04061835566846 |
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What is the temperature and pH range that this product effectively blocks thiol groups?
1 answer-
Helpful?
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What is the solubility of Product 64306, S-Methyl methanethiosulfonate?
1 answer-
Product 64306, S-Methyl methanethiosulfonate, is practically insoluble in water. It is soluble in methylene chloride. Several references do report that S-Methyl methanethiosulfonate is soluble in isopropanol at a 200mM concentration. References are provided below: 1. Yan, W., et al., "Quantitative Proteomic Analysis to Profile Dynamic Changes in the Spatial Distribution of Cellular Proteins", in Methods in Molecular Biology, Vol. 432: Organelle Proteomics, pp. 389-401 (Humana Press, 2008).2. Sadowski, P.G., et al., Quantitative proteomic approach to study subcellular localization of membrane proteins. Nature Protocols, 1, 1778-1789 (2006).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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