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27102

Sigma-Aldrich

Citric acid monohydrate

puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

Synonim(y):

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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About This Item

Wzór liniowy:
HOC(COOH)(CH2COOH)2 · H2O
Numer CAS:
5949-29-1
Masa cząsteczkowa:
210.14
Beilstein:
4018641
Numer WE:
201-069-1
Numer MDL:
MFCD00149972
Kod UNSPSC:
12352100
Identyfikator substancji w PubChem:
57648219
NACRES:
NA.21

klasa czystości

puriss.

Próba

99.5-100.5% (based on anhydrous substance)

Postać

grit

jakość

meets analytical specification of Ph. Eur., BP, USP, E330

zanieczyszczenia

residual solvents, complies
≤0.0005% heavy metals (as Pb)
7.5-8.8% water (Karl Fischer)

pozostałość po prażeniu

≤0.05% (as SO4)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

ślady anionów

chloride (Cl-): ≤50 mg/kg
oxalate (as oxalic acid): ≤100 mg/kg
sulfate (SO42-): ≤100 mg/kg

ślady kationów

As: ≤1 mg/kg
Ca: ≤200 mg/kg
Cu: ≤10 mg/kg
Fe: ≤10 mg/kg
Hg: ≤1 mg/kg
Pb: ≤1 mg/kg
Zn: ≤10 mg/kg

przydatność

complies for appearance of solution
complies for identity (IR)
complies for reaction against H2SO4

ciąg SMILES

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

Klucz InChI

YASYEJJMZJALEJ-UHFFFAOYSA-N

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Opis ogólny

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061 ± 123)Jmol-1

Zastosowanie

Citric acid monohydrate may be used in the diltiazem hydrochloride (drug) and melt extruded Eudragit RS PO (polymer) formulations. It improves the solubility of drug in the polymer matrix. It may be used to prepare citrate buffer for use in the intravital microscopic studies of adhesion and aggregation of platelets.

Piktogramy

Exclamation mark
GHS07

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H319,H335

Klasyfikacja zagrożeń

Eye Irrit. 2 - STOT SE 3

Organy docelowe

Respiratory system

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

345.0 °F - closed cup

Temperatura zapłonu (°C)

173.9 °C - closed cup

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Gloves

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Certyfikaty analizy (CoA)

Lot/Batch Number
BCCK3277
BCCH5300
BCCG2090
BCCD2310
BCBT5913

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Sigma-Aldrich

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Citric acid

Sandra U Schilling et al.
International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)
Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem
S Massberg et al.
The Journal of experimental medicine, 189(8), 1255-1264 (1999-04-20)
Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases, including myocardial infarction and stroke. Platelet adhesion and aggregation during ischemia-reperfusion are thought to be the initial steps leading to remodeling and reocclusion of the postischemic vasculature.
Enthalpy of solution of oxalic, succinic, adipic, maleic, malic, tartaric, and citric acids, oxalic acid dihydrate, and citric acid monohydrate in water at 298.15K.
Apelblat A.
The Journal of Chemical Thermodynamics, 18(4), 351-357 (1986)
Carolina Ganss et al.
PloS one, 10(6), e0123889-e0123889 (2015-06-16)
For preventing erosive wear in dentine, coating with adhesives has been suggested as an alternative to fluoridation. However, clinical studies have revealed limited efficacy. As there is first evidence that Sn(2+) increases bond strength of the adhesive Clearfil SE (Kuraray)
T Ulens et al.
Journal of animal science, 93(2), 627-636 (2014-12-31)
This study evaluated the effect of feed form and grinding intensity of the pig diet and the interaction between both on the particulate matter (PM) concentrations inside a pig nursery and the growth performances of weanling pigs. Four diets were
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