438075

Longdaysin

A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIα and CKIδ activities with moderate selectivity over Cdk7 and Erk2.

• Synonim(y): Longdaysin, 9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine, Casein Kinase I Inhibitor VII, Casein Kinase I Inhibitor VII, 9-Isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine
• Wzór empiryczny (zapis Hilla): C₁₆H₁₆F₃N₅
• Numer CAS: 1353867-91-0
• Masa cząsteczkowa: 335.33
• Numer MDL: MFCD20527323
• Kod UNSPSC: 12352200

Właściwości

• Poziom jakości: 100
• Próba: ≥99% (HPLC)
• Postać: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• kolor: white
• rozpuszczalność: DMSO: 50 mg/mL
• Warunki transportu: wet ice
• temp. przechowywania: 2-8°C

Opis

Opis ogólny

A cell-permeable purine compound that acts as a reversible and ATP-competitive dual inhibitor of CKIα and CKIδ activities (IC₅₀ = 5.6 and 8.8 µM) with moderate selectivity over Cdk7 and Erk2 (IC₅₀ = 29 and 52 µM). Shown to block CKIα/δ-mediated phosphorylation of PER1, a clock protein, (IC₅₀ ~ 9 µM) and repress PER1 proteasomal degradation, and lengthen the circadian period in U2OS cells (by ~ 13 hrs at 10 µM) much more effectively than Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) and IC261 (Cat. No. 400090) and in larval zebra fish.

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Harmful (C)

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Inne uwagi

Hirota, T., et al. 2010. PLoS Biol.8, e1000559.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable