U104

UK 14,304

• 別名: 5-ブロモ-N-(2-イミダゾリン-2-イル)-6-キノキサリンアミン, 5-ブロモ-N-(4,5-ジヒドロ-1H-イミダゾール-2-イル)-6-キノキサリンアミン, ブリモニジン
• 実験式（ヒル表記法）: C₁₁H₁₀BrN₅
• CAS番号: 59803-98-4
• 分子量: 292.13
• MDL番号: MFCD00153878
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277812
• NACRES: NA.77

特性

• 品質水準: 100
• 溶解性: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL; DMSO: >6.5 mg/mL; ethanol: <8 mg/mL (warm); H₂O: insoluble
• SMILES記法: Brc1c(NC2=NCCN2)ccc3nccnc13
• InChI: 1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
• InChI Key: XYLJNLCSTIOKRM-UHFFFAOYSA-N
• 遺伝子情報: human ... ADRA1A(148) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

詳細

アプリケーション

UK 14,304 has been used for the activation of extracellular signal-regulated kinase (ERK) in epicardial coronary artery culture

UK 14,304 has been used in myenteric neurons to study the inhibition of R-type calcium currents. UK 14,304 has also been used for immunofluorescence microscopy assays.

生物化学的／生理学的作用

UK 14,304 is an α2-adrenoceptor agonist. UK 14,304 inhibits hormone-sensitive lipase (HSL) activity and suppresses lipogenesis in adipose tissue.

特徴および利点

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

調製ノート

UK 14,304 is soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (<0.8 mg/mL), DMSO (>6.5 mg/ml) and ethanol (<8 mg/mL). However, it is insoluble in water.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable