C5366

二ヨウ化クロリソンダミン

≥98% (HPLC), nicotinic acetylcholine receptor antagonist, solid

• 別名: 4,5,6,7-テトラクロロ-2,3-ジヒドロ-2-メチル-2-[2-(トリメチルアンモニオ)エチル]-2H-イソインドリウム二ヨウ化物
• 実験式（ヒル表記法）: C₁₄H₂₀Cl₄I₂N₂
• CAS番号: 96750-66-2
• 分子量: 611.94
• UNSPSC Code: 12352116
• PubChem Substance ID: 24724443
• NACRES: NA.77
• MDL number: MFCD01074794
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: protect from light

特性

• 製品名: 二ヨウ化クロリソンダミン, ≥98% (HPLC), white, solid
• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: white
• solubility: H₂O: ≥2 mg/mL, DMSO: >20 mg/mL
• storage temp.: 2-8°C
• SMILES string: [I-].[I-].C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1
• InChI: 1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
• InChI key: FPNVAOZHQUJJJQ-UHFFFAOYSA-L

詳細

Application

Chlorisondamine diiodide has been used:

• as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis[1]
• as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction[2]
• as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress[3]

Biochem/physiol Actions

不可逆性かつ持続的に作用するニコチン性アセチルコリンレセプタ-のアンタゴニストです。

Chlorisondamine diiodide mediates ganglionic and central blockade.[4]

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302,H400
• pcodes: P273 - P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1
• 保管分類: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves