B4063

BIMU8 水和物

≥98% (HPLC)

• 別名: 2,3-ジヒドロ-N-[(3-endo)-8-メチル-8-アザビシクロ[3.2.1]オクト-3-イル]-3-(1-メチルエチル)-2-オキソ-1H-ベンズイミダゾール-1-カルボキサミド塩酸塩(1:1) 水和物
• 実験式（ヒル表記法）: C₁₉H₂₆N₄O₂·HCl · xH₂O
• CAS番号: 134296-40-5
• 分子量: 378.90 (anhydrous basis)
• MDL番号: MFCD17215946
• UNSPSCコード: 12352200
• PubChem Substance ID: 329773228
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 保管条件: desiccated
• 色: off-white to light tan
• 溶解性: H₂O: ≥5 mg/mL
• 保管温度: 2-8°C
• SMILES記法: Cl.N1([C@@H]2C[C@H](C[C@H]1CC2)NC(=O)N3c4c(cccc4)N(C3=O)C(C)C)C.O
• InChI: 1S/C19H26N4O2.ClH.H2O/c1-12(2)22-16-6-4-5-7-17(16)23(19(22)25)18(24)20-13-10-14-8-9-15(11-13)21(14)3;;/h4-7,12-15H,8-11H2,1-3H3,(H,20,24);1H;1H2/t13-,14+,15-;;
• InChI Key: HZJJVFOOACXPTH-XZAJHMFNSA-N

詳細

生物化学的／生理学的作用

BIMU8 hydrate is a potent 5-HT₄ serotonin receptor agonist.

BIMU8 hydrate is a potent 5-HT₄ serotonin receptor agonist. Serotonin (5-HT) is a major neurotransmitter that acts through a family of GPCRs and one ion channel. 5-HT₄ receptor is GPCR expressed in many tissues, including brain, and modulates dopamine secretion, learning, and memory. BIMU8 is a full agonist at 5-HT₄, but it binds differently than the endogenous ligand, 5-HT, shown through site-directed mutagenesis studies. It depolarizes neurons and was used to localize 5-HT₄ to somatic but not dendritic regions of CA1 pyramidal neurons.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable