SML1371

Prucalopride

≥98% (HPLC)

• 別名: 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide
• 実験式（ヒル表記法）: C₁₈H₂₆ClN₃O₃
• CAS番号: 179474-81-8
• 分子量: 367.87
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: COCCCN1CCC(NC(C2=CC(Cl)=C(N)C3=C2OCC3)=O)CC1
• InChI: 1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
• InChI Key: ZPMNHBXQOOVQJL-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

In healthy male individuals, prucalopride decreases the display of esophageal acid and promotes gastric emptying.[1] It is effective, safe and shows good tolerance for the treatment of men with chronic constipation.[2]

Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activity.

Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activity. 5-HT4 receptors are GPCRs that are expressed in the CNS and peripheral tissues. The receptor has a role in GI motility disorders such as irritable bowel syndrome and idiopathic constipation. Agonists are prokinetic and of potential use for disoroders of reduced motility. Prucalopride is a selective 5-HT4 serotonin receptor agonist with enterokinetic activities. Prucalopride has pK(i) values of 8.60 and 8.10 for the human 5-HT(4a) and 5-HT(4b) receptor, respectively, and at least 290-fold selectivity for 5-HT4 over other serotonin and dopamine receptors.

安全性情報

• ピクトグラム: GHS07,GHS09
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335,H400
• 注意書き: P273 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable