Carbonyl Cyanide m-Chlorophenylhydrazone, Protonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol.
Protonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol. Binds with cytochrome c oxidase with high affinity (Kd = 270 nM). Inhibits transport processes and depresses growth.
生物化学的／生理学的作用
Cell permeable: no
Kd = 270 nM in binding with cytochrome c oxidase
Primary Target cytochrome c oxydase
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Harmful (C)
再構成
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.
その他情報
Bona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533. Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun.7, 272.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
International journal of molecular sciences, 23(9) (2022-05-15)
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