T6397

3,3′,5-Triiodo-L-thyronine sodium salt

powder, BioReagent, suitable for cell culture

• Sinonimo/i: Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T₃
• Formula empirica (notazione di Hill): C₁₅H₁₁I₃NNaO₄
• Numero CAS: 55-06-1
• Peso molecolare: 672.96
• Beilstein: 8179867
• Numero CE: 200-223-5
• Numero MDL: MFCD00002594
• Codice UNSPSC: 12352209
• ID PubChem: 24900372
• NACRES: NA.77
• Origine biologica: synthetic
• Stato: powder
• Saggio: ≥95%

Proprietà

• Origine biologica: synthetic
• Livello qualitativo: 200
• Nome Commerciale: BioReagent
• Saggio: ≥95%
• Stato: powder
• Potenza: 0.02-50 ng/mL (lit.)
• tecniche: cell culture | mammalian: suitable
• Solubilità: ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to yellow
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• Stringa SMILE: [Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1; SBXXSUDPJJJJLC-YDALLXLXSA-M
• Informazioni sul gene: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

Descrizione

Descrizione generale

3,3′,5′-Triiodo-L-thyronine (T₃) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level.[1][2] Thyroxine (T₄) serves as a precursor for T₃ and is generated in extrathyroidal tissues.[3]

Applicazioni

3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice.[4] It has also been used In cell culturing of hippocampal,[5] retinal,[6] proximal tubule and glomerular explant.[7]

Azioni biochim/fisiol

3,3′,5′-Triiodo-L-thyronine (T₃) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T₃ regulates cell differentiation and protein expression. The interaction of T₃ with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes.[8] The level of circulating T₃ hormone is reduced in hypothyroidism.[1]

Stato fisico

powder-20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Ricostituzione

To prepare 20 μg/ml stock solution: add 1ml 1N NaOH per mg 3,3′, 5-triiodo-L-thyronine; gently swirl to dissolve. To this, add 49 ml sterile medium per ml 1N NaOH added.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)