Product SRE0011 is suitable for the manufacturing of diagnostic reagents and kits. It must be stored at -20°C to maintain the 1-year warranty. Storage at 2-8°C is outside the recommended range, and the effect of prolonged storage at 2-8°C on the product's stability is unknown.
SRE0011
γ-globuline
Suitable for manufacturing of diagnostic kits and reagents, ≥99% (agarose gel electrophoresis)
Sinonimo/i:
γ-globulina bovina
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1 G
70,40 €
5 G
232,00 €
10 G
537,00 €
25 G
939,00 €
100 G
2.860,00 €
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Cambia visualizzazione
1 G
70,40 €
5 G
232,00 €
10 G
537,00 €
25 G
939,00 €
100 G
2.860,00 €
About This Item
Prodotti consigliati
Livello qualitativo
Saggio
≥99% (agarose gel electrophoresis)
Stato
powder
Composizione
NaCl, ≤4%
applicazioni
diagnostic assay manufacturing
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
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Descrizione generale
Frazione di proteine plasmatiche ricca di anticorpi
La gammaglobulina bovina (BGG) è un componente importante del sistema immunitario delle mucche e di altri bovini. La BGG è presente nel sangue dei bovini ed è utilizzata principalmente per la produzione di prodotti sanitari come i vaccini, i sieri e i reagenti diagnostici. La BGG può essere inoltre usata per curare alcune patologie come l′epatite B, oltre che per rafforzare le difese immunitarie in altri animali o negli esseri umani.
Applicazioni
La γ-globulina bovina è stata utilizzata come stimolo immunologico negli studi sui meccanismi di immunotolleranza.
γ-Globulins from bovine blood has been used along with polyethylene glycol (PEG) to investigate the kinetics of liquid-liquid phase separation (LLPS) in its temporary and arrested state.[4] It has also been used as a parent solution to prevent bacterial growth and study the antibody system with LLPS and highly elevated protein concentrations in arrested transition.[5]
Azioni biochim/fisiol
Immunoglobulins are implicated in the activation of the complement system and the opsonization of microbes for phagocytosis. It is also involved in the neutralization of toxins and viruses and blocks the attachment of microbes to mucosal surfaces. They protect our bodies against fungi, viruses, and bacteria. Immunodeficiency is associated with recurrent infectious diseases.[2]
Nota sulla preparazione
Prepared from Cohn Fraction II, III
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Certificati d'analisi (COA)
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I clienti hanno visto anche
Blood
Sturkie's Avian Physiology, 167-191, 167-191 (2015)
Stefano Da Vela et al.
Soft matter, 13(46), 8756-8765 (2017-11-14)
We investigate the transition of the phase separation kinetics from a complete to an arrested liquid-liquid phase separation (LLPS) in mixtures of bovine γ-globulin with polyethylene glycol (PEG). The solutions feature LLPS with upper critical solution temperature phase behavior. At
Anita Girelli et al.
Molecular pharmaceutics, 18(11), 4162-4169 (2021-10-13)
Antibody therapies are typically based on high-concentration formulations that need to be administered subcutaneously. These conditions induce several challenges, inter alia a viscosity suitable for injection, sufficient solution stability, and preservation of molecular function. To obtain systematic insights into the
Justiz Vaillant AA, et al.
Immunoglobulin (2021)
Harry W Schroeder et al.
The Journal of allergy and clinical immunology, 125(2 Suppl 2), S41-S52 (2010-03-05)
Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains. They can be separated functionally into variable domains that bind antigens and constant domains that specify effector functions, such as activation of complement or binding to Fc receptors.
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Can Gamma-Globulins be stored at 2 - 8 C without affecting shelf life, considering the Certificate of Analysis specifies a storage temperature of -20 C?
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Dear sir or madam, Can you please let me know what is the shelf life for this reference
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This product is not assigned an expiration date. It is assigned a recommended retest date of 2 years after the quality release date. A recommended retest date is the time during which the product is expected to remain within established stability specifications, provided that it has been stored under defined conditions. After the Retest Date, product samples should be examined to ensure that the product is still in compliance with the established specifications.
For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.
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