G7516

γ-globuline

≥97% (agarose gel electrophoresis)

• Sinonimo/i: γ-globulina bovina
• Numero CAS: 9007-83-4
• MDL number: MFCD00055220
• EC Number: 232-706-1
• NACRES: NA.61
• UNSPSC Code: 12352202
• Form: powder
• Assay: ≥97% (agarose gel electrophoresis)
• Biological source: bovine blood

Proprietà

• biological source: bovine blood
• Quality Segment: 300
• assay: ≥97% (agarose gel electrophoresis)
• form: powder
• composition: NaCl, ≤5%
• solubility: 0.9% NaCl: soluble 50 mg/mL
• storage temp.: −20°C

Descrizione

General description

Frazione di proteine plasmatiche ricca di anticorpi

La gammaglobulina bovina (BGG) è un componente importante del sistema immunitario delle mucche e di altri bovini. La BGG è presente nel sangue dei bovini ed è utilizzata principalmente per la produzione di prodotti sanitari come i vaccini, i sieri e i reagenti diagnostici. La BGG può essere inoltre usata per curare alcune patologie come l′epatite B, oltre che per rafforzare le difese immunitarie in altri animali o negli esseri umani.

The γG globulins of bovine serum are categorized by anion exchange chromatography, immunoelectrophoresis, zone electrophoresis, ultracentrifugation, and analysis of the products of papain digestion. They have properties similar to analogous components of human serum. This was determined by the methods such as: gel filtration, immunoelectrophoresis, anion exchange chromatography, ultracentrifugation, and reduction with mercaptoethanol. Fast and slow γG globulins were classified on the basis of differences in electrophoretic migration rates, chromatographic elution positions, and biological activities (complement fixation). Bovine γA was conditionally found in immunoelectrophoretic analyses of serum and chromatographic fractions.

Application

La γ-globulina bovina è stata utilizzata come stimolo immunologico negli studi sui meccanismi di immunotolleranza.

γ-globulin has been used as an immunological challenge in studies of mechanisms of immunotolerance.[1]
Bovine γ-globulins were used to study the constituents and pH changes in protein rich hyaluronan solution affecting the bio-tribological properties of artificial articular joints.[2] It is also used to determine immunoglobulin G in bovine colostrum and milk by direct biosensor SPR-immunoassay.
Bovine γ-globulin was used in rapid screening for monensin residues in poultry plasma by a dry reagent dissociation enhanced lanthanide fluoroimmunoassay.[3] It was also tested for the effects of solution properties on solute and permeate flux in bovine serum albumin-IgG ultrafiltration. [4]

Preparation Note

Prepared from plasma

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)