T1001
Thyroglobulin from bovine thyroid
powder, ≥90% (agarose gel electrophoresis)
Sinonimo/i:
Globulins thyro, Thyractin
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About This Item
Prodotti consigliati
Origine biologica
bovine thyroid
Saggio
≥90% (agarose gel electrophoresis)
Forma fisica
powder
PM
~670 kDa
Composizione
Iodine, ≥0.20%
Tenore di azoto
13.0-16.0% total
Ceneri
≤4%
Solubilità
H2O: 20 mg/mL
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
cow ... TG(280706)
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Applicazioni
Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Azioni biochim/fisiol
Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Certificati d'analisi (COA)
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