T1001
Thyroglobulin from bovine thyroid
powder, ≥90% (agarose gel electrophoresis)
Sinonimo/i:
Globulins thyro, Thyractin
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Cambia visualizzazione
| A voi/SKU | Disponibilità | Prezzo |
|---|---|---|
100 mg | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 234,00 € |
500 mg | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 602,00 € |
1 g | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 1390,00 € |
5 g | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 3020,00 € |
Informazioni su questo articolo
Form:
powder
Assay:
≥90% (agarose gel electrophoresis)
Biological source:
bovine thyroid
Mol wt:
~670 kDa
234,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Servizio Tecnico
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Permettici di aiutartibiological source
bovine thyroid
Quality Segment
assay
≥90% (agarose gel electrophoresis)
form
powder
mol wt
~670 kDa
composition
Iodine, ≥0.20%
nitrogen analysis
13.0-16.0% total
ash
≤4%
solubility
H2O: 20 mg/mL
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... TG(280706)
Application
Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Biochem/physiol Actions
Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.
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Questo articolo | |||
|---|---|---|---|
| assay ≥90% (agarose gel electrophoresis) | assay - | assay ≥90% (SDS-PAGE) | assay ≥95% (PAGE) |
| biological source bovine thyroid | biological source bovine thyroid | biological source bovine thyroid | biological source human thyroid |
| mol wt ~670 kDa | mol wt ~670 kDa | mol wt - | mol wt - |
| form powder | form powder | form lyophilized solid | form lyophilized |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility H2O: 20 mg/mL | solubility - | solubility aqueous buffer: soluble, water: soluble | solubility - |
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Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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