SML1410

A-366

≥98% (HPLC)

• Sinonimo/i: 5′-Methoxy-6′-[3-(1-pyrrolidinyl)propoxy]-spiro[cyclobutane-1,3′-[3H]indol]-2′-amine
• Formula empirica (notazione di Hill): C₁₉H₂₇N₃O₂
• Numero CAS: 1527503-11-2
• Peso molecolare: 329.44
• Numero MDL: MFCD28133403
• Codice UNSPSC: 12352202
• ID PubChem: 329825857
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to beige
• Solubilità: DMSO: 10 mg/mL, clear
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: NC1=NC2=CC(OCCCN3CCCC3)=C(OC)C=C2C14CCC4
• InChI: 1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21); BKCDJTRMYWSXMC-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

A-366 is an SGC chemical probe for G9a/GLP, developed in collaboration with Abbvie. A-366 is a potent, selective inhibitor of the histone methyltransferase G9a. The IC₅₀ values for G9a inhbition in enzymatic and cell based assays are 3.3 and approximately 3 μM, respectively. A-366 has little or no detectable activity against a panel of 21 other methyltransferases. For full characterization details, please visit the A-366 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Caratteristiche e vantaggi

A-366 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Altre note

A-366 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the A-366 probe summary on the Chemical Probes Portal website.

Informazioni sulla sicurezza

• Pittogrammi: GHS09
• Avvertenze: Warning
• Indicazioni di pericolo: H400
• Consigli di prudenza: P273 - P391 - P501
• Classi di pericolo: Aquatic Acute 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable