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R9782

Sigma-Aldrich

RS-1

≥98% (HPLC)

Sinonimo/i:

3-[(benzylamino)sulfonyl]-4-bromo-N-(4-bromophenyl)benzamide, 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]-benzamide, RAD51-stimulatory compound 1

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105,00 €
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425,00 €

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5 MG
105,00 €
25 MG
425,00 €

About This Item

Formula empirica (notazione di Hill):
C20H16Br2N2O3S
Numero CAS:
312756-74-4
Peso molecolare:
524.23
Numero MDL:
MFCD00348720
Codice UNSPSC:
12352200
ID PubChem:
329824048
NACRES:
NA.77

105,00 €

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Saggio

≥98% (HPLC)

Stato

powder

Colore

off-white to light tan

Solubilità

DMSO: ≥10 mg/mL

Temperatura di conservazione

room temp

Stringa SMILE

Brc1ccc(NC(=O)c2ccc(Br)c(c2)S(=O)(=O)NCc3ccccc3)cc1

InChI

1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)
SWKAVEUTKGKHSR-UHFFFAOYSA-N

Applicazioni

RS-1 has been shown to enhance CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.
RS-1 has been used:
  • as a homology-directed repair (HDR) agonist to study its effects on in human hematopoietic stem/progenitor cells (HSPCs)[1]
  • as HDR agonist to analyze its effects on DNA repair modulation in human induced pluripotent stem (iPS) cells[2]
  • as RAD51 agonist to study its effects on double-stranded break repair[3]

Azioni biochim/fisiol

RS-1 (RAD51-stimulatory compound 1) is a stimulator of the human homologous recombination (HR) protein RAD51. RS-1 stimulates binding of hRAD51 to single stranded DNA (ssDNA) and enhances recombinogenic activity by stabilizing the active form of hRAD51 filaments without inhibiting hRAD51 ATPase activity. RS-1 has been shown to enhance CRISPR-Cas9 knock-in efficiency in HEK293A cells and has been shown to enhance both TALEN and Cas9-mediated knock-in efficiency in rabbits.
RS-1 is a stimulator of the human homologous recombination protein RAD51.
RS-1 is a sulfonamido-benzamide compound.[4]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
119K4711V
0000201249
056M4710V
046M4750V

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Xue Wang et al.
BioMed research international, 2019, 7878906-7878906 (2019-11-07)
It has been reported that paclitaxel administration could cause sensorineural hearing loss, and Wnt activation is important for the development and cell protection of mouse cochlea. However, the effect of Wnt signaling in spiral ganglion neurons (SGNs) damage induced by
Liqian Zhu et al.
Veterinary research, 48(1), 45-45 (2017-09-09)
Bovine herpesvirus 1 (BoHV-1) infection enhanced the generation of inflammatory mediator reactive oxidative species (ROS) and stimulated MAPK signaling that are highly possibly related to virus induced inflammation. In this study, for the first time we show that BoHV-1 infection
Siti Nur Syahirah Ahmad et al.
Foods (Basel, Switzerland), 10(2) (2021-01-31)
This study aims to investigate the effect of different vegetable oils and frying cycles on acrylamide formation during the intermittent frying of beef nuggets. Different vegetable oils, palm olein (PO), red palm olein (RPO), sunflower oil (SFO), and soybean oil
Jordan Pinder et al.
Nucleic acids research, 43(19), 9379-9392 (2015-10-03)
CRISPR is a genome-editing platform that makes use of the bacterially-derived endonuclease Cas9 to introduce DNA double-strand breaks at precise locations in the genome using complementary guide RNAs. We developed a nuclear domain knock-in screen, whereby the insertion of a
Krishanthi Jayathilaka et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(41), 15848-15853 (2008-10-09)
RAD51 and other members of the RecA family of strand exchange proteins assemble on ssDNA to form presynaptic filaments, which carry out the central steps of homologous recombination. A microplate-based assay was developed for high-throughput measurement of hRAD51 filament formation
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Articoli

Small Molecule CRISPR Enhancers

Modulation of homology-directed repair (HDR) within the context of CRISPR-genome editing has led to the identification of small molecules that enhance CRISPR-mediated HDR efficiency in various cell types.

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