M6908
Myeloperoxidase from human leukocytes
lyophilized powder, ≥50 units/mg protein
Sinonimo/i:
MPO, Peroxidase, myelo
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450,00 €
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About This Item
Numero CAS:
Numero MDL:
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human leucocytes
Livello qualitativo
Stato
lyophilized powder
Attività specifica
≥50 units/mg protein
Solubilità
H2O: soluble
aqueous buffers such as 50 mM sodium acetate: soluble (Freezing of the enzyme in solution may result in a substantial loss of activity.)
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Stringa SMILE
[O+H2]O[O-]
InChI
1S/H2O3/c1-3-2/h1-2H
JSPLKZUTYZBBKA-UHFFFAOYSA-N
Informazioni sul gene
human ... MPO(4353)
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Descrizione generale
Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24.[1] The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.[2]
Applicazioni
Myeloperoxidase from human leukocytes has been used:
- as a standard to quantify the neutrophil (polymorphonuclear cell [PMN]) infiltration in lung tissue[6]
- as a neutrophil extracelullar trap (NET) component to stimulate 106 dendritic cells or 106 macrophages[7]
- as a standard in myeloperoxidase (MPO) assay to measure pancreatic MPO[8]
Azioni biochim/fisiol
Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells.[9] MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease.[10] MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H2O2).[3]
Altre note
Lysosomal heme-containing protein.
Definizione di unità
One unit of myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25 °C
Stato fisico
Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride
Risultati analitici
Source material tested and found negative for antibody to HIV and for HBSAG.
Inibitore
N° Catalogo
Descrizione
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Substrato
N° Catalogo
Descrizione
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Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
The localization of the human myeloperoxidase gene is in close proximity to the translocation breakpoint in acute promyelocytic leukemia.
Chang KS
Leukemia, 1(15), 458-462 (1987)
Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice.
Bergeron Y
Infection and Immunity, 66(3), 912-922 (1998)
Clinical manifestation of myeloperoxidase deficiency.
Lanza F
Journal of Molecular Medicine, 76(10), 676-681 (1998)
Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis
Romac JMJ, et al.
Nature Communications, 9(1715), 1-10 (2018)
Sharbel Weidner Maluf et al.
Genetics and molecular biology, 43(2), e20180390-e20180390 (2020-06-20)
The objective of this study was to evaluate the level of genomic instability in patients with celiac disease and to establish a relationship between inflammation, oxidative stress, and DNA damage in these patients. Myeloperoxidase (MPO) activity, adenosine deaminase, nitric oxide
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