SRP6303
Apolipoprotein E from human plasma
≥95% (SDS-PAGE)
Szinonimák:
ApoE
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352202
NACRES:
NA.32
Javasolt termékek
Általános leírás
Apolipoprotein E (ApoE) is an important constituent of all plasma lipoproteins. The concentration of Apo E in normal plasma is 5 mg/100mL. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. It exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. The gene encoding this protein is localized on human chromosome 19q13.32.
Biokémiai/fiziológiai hatások
Apolipoprotein E (ApoE) serves as a ligand for low density receptors and participates in the transport and redistribution of cholesterol and other lipids. Other functions include immunoregulation, cell growth modulation and differentiation. Apo E is thought to be involved in tissue repair as increased amounts of the protein are found at sites of peripheral nerve injury and regeneration. A mutant form is associated with familial type III hyperlipoproteinemia. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. ApoE′s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the low-density lipoprotein (LDL) receptor (apo B/E).
Fizikai forma
Frozen in 50 mM NH4HCO3, pH 8.0.
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Analitikai tanúsítványok (COA)
Lot/Batch Number
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Az ügyfelek ezeket is megtekintették
Apolipoprotein E isoforms and lipoprotein metabolism.
Phillips MC
IUBMB Life, 66(9), 616-623 (2014)
Apolipoprotein E-low density lipoprotein receptor binding: study of protein-protein interaction in rationally selected docked complexes.
Prevost M and Raussens V
Proteins: Structure, Function, and Genetics, 55(4), 874-884 (2004)
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
Deelen J
Aging Cell, 10(4), 686-698 (2011)
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.
Mahley RW
Journal of Lipid Research, 40(11), 1933-1949 (1999)
Karol Kaiser et al.
Nature communications, 10(1), 1498-1498 (2019-04-04)
WNTs are lipid-modified proteins that control multiple functions in development and disease via short- and long-range signaling. However, it is unclear how these hydrophobic molecules spread over long distances in the mammalian brain. Here we show that WNT5A is produced
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