SRP6006
IL-1RA murine
recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
Szinonimák:
ICIL-1RA, IL-1ra3, IL1 inhibitor, IL1F3, IRAP
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352200
NACRES:
NA.32
Javasolt termékek
biológiai forrás
mouse
rekombináns
expressed in E. coli
Teszt
≥98% (SDS-PAGE)
Forma
lyophilized
molekulatömeg
17.4 kDa
kiszerelés
pkg of 50 μg
technika/technikák
activity assay: suitable
szennyeződések
Endotoxin, tested
NCBI elérési szám
UniProt elérési szám
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
Géninformáció
mouse ... IL-1RA(16181)
Általános leírás
Research area: IMMUNO AND CKS
Interleukin-1 receptor antagonist (IL-1 RA) is a member of the interleukin 1 cytokine family. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL-1RA mouse recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2.
Interleukin-1 receptor antagonist (IL-1 RA) is a member of the interleukin 1 cytokine family. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL-1RA mouse recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2.
Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1 ra Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques.
Alkalmazás
IL-1RA murine has been used as an antagonist to the interleukin-1 receptor in fibroblasts.
Biokémiai/fiziológiai hatások
Interleukin-1 receptor antagonist (IL-1Ra) protein mediates the inhibition of interleukin 1-α (IL1A) and interleukin 1-β (IL1B) activities. It is also involved in the modulation of IL-1 related immune and inflammatory responses. A polymorphism in the IL-1Ra gene is reported to be associated with an increased risk of osteoporotic fractures and gastric cancer. IL-1Ra is effective in treating bronchopulmonary dysplasia in murine models.This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B) and modulates a variety of interleukin 1 related immune and inflammatory responses.
Fizikai forma
Lyophilized from H?O containing NaHCO?
Feloldás
Centrifuge the vial prior to opening. Reconstitute in sterile ddH?O to a concentration ? 100 μg/ml. This solution can then be diluted into other aqueous buffers.
Egyéb megjegyzések
The IL1RA is purified by proprietary chromatographic techniques.
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
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Analitikai tanúsítványok (COA)
Lot/Batch Number
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Athanasios Didangelos et al.
Scientific reports, 6, 21607-21607 (2016-02-24)
Spinal cord injury is characterized by acute cellular and axonal damage followed by aggressive inflammation and pathological tissue remodelling. The biological mediators underlying these processes are still largely unknown. Here we apply an innovative proteomics approach targeting the enriched extracellular
W P Arend et al.
Annual review of immunology, 16, 27-55 (1998-05-23)
The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce any intracellular response. Two structural variants of IL-1Ra have previously been described: a 17-kDa form that is secreted from
Christine B Bui et al.
Frontiers in immunology, 10, 1480-1480 (2019-07-30)
Pulmonary hypertension secondary to bronchopulmonary dysplasia (BPD-PH) represents a major complication of BPD in extremely preterm infants for which there are currently no safe and effective interventions. The abundance of interleukin-1 (IL-1) is strongly correlated with the severity and long-term
The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer.
E M El-Omar et al.
Nature, 412(6842), 99-99 (2002-01-26)
B L Langdahl et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 15(3), 402-414 (2000-04-06)
Interleukin-1beta (IL-1beta) is a potent stimulator of bone resorption, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1 receptor antagonist (IL-1ra) is a competitive inhibitor of IL-1beta effects and the biological effects of IL-1beta are
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